CALCIUM SIGNALING AND PREFRONTAL DEFICITS IN SCHIZOPHRENIA

精神分裂症的钙信号传导和前额叶缺陷

• 批准号: 7958212
• 负责人: David McCormick
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958212
• 关键词: Affinity; Calcium Signaling; Cognition; Computer Retrieval of Information on Scientific Projects Database; Disease; Dopamine; Dopamine D1 Receptor; Dopamine Receptor; Family; Funding; Grant; Immunoelectron Microscopy; Institution; Interneurons; Laboratories; Ligands; Monkeys; Play; Prefrontal Cortex; Primates; Proteins; Reporting; Research; Research Personnel; Resources; Role; Schizophrenia; Signal Transduction; Source; Testing; United States National Institutes of Health; Universities; base; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a subcontract of a Conte Center grant based at Yale University. During the reporting period, we used immunoelectron microscopy and quantitative analyses developed in our laboratory to study the distribution of D1 family dopamine receptors (D1 and D5) and signal transduction proteins in normal monkey prefrontal cortex as well as in various interneuron subpopulations. We tested the hypothesis that differential distribution of D1 and D5, receptors that differ in their affinity for the endogenous ligand dopamine, play a role in the inverted U curve relationship between D1 family dopamine receptor stimulation and prefrontal functioning. These studies provided us with a basis for understanding how dopamine controls cognition in primates and how this control might be disordered in schizophrenia.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究是耶鲁大学康特中心资助的一项研究。 在本报告期间，我们使用免疫电镜和定量分析，在我们的实验室开发的D1家族多巴胺受体（D1和D5）和信号转导蛋白在正常的猴子前额叶皮层以及在各种interneuron亚群的分布进行了研究。 我们测试的假设，即差异分布的D1和D5，受体的内源性配体多巴胺的亲和力不同，发挥作用的倒U型曲线之间的关系D1家族多巴胺受体刺激和前额叶功能。 这些研究为我们理解多巴胺如何控制灵长类动物的认知以及这种控制如何在精神分裂症中紊乱提供了基础。