Genetics /developmental neuropharmacology research unit

遗传学/发育神经药理学研究单位

• 批准号: 6344965
• 负责人: RAYMOND CROWE
• 金额: $ 11.11万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6344965
• 关键词: behavioral genetics; developmental neurobiology; disease /disorder classification; disease /disorder etiology; gene environment interaction; gene mutation; genetic mapping; genetic susceptibility; human data; human population genetics; mental disorder diagnosis; pharmacogenetics; schizophrenia

Overall Aims 1. To search for vulnerability loci for schizophrenia. 2. To explore the genetic controls of neurodevelopment as they rate to schizophrenia and other neurodevelopmental brain disorders. 3. To explore the relative roles of genetic and environmental factors in the production of neurodevelopmental disorders. 4. To research for more primary phenotypes (endophenotypes, i.e., personality traits, characteristic brain morphology, patterns of cognitive dysfunction) that may be more closely linked to genotypes than syndromal, criteria-based diagnostic entities.

总体目标1。寻找精神分裂症的易感基因。2.探讨神经发育的遗传控制与精神分裂症和其他神经发育性脑疾病的关系。3.探讨遗传和环境因素在神经发育障碍发生中的相对作用。4.研究更多的主要表型(内表型，即人格特征、特征性脑形态、认知功能障碍的模式)，这些表型可能比症状、基于标准的诊断实体更接近于基因类型。