NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION

部分睡眠剥夺对神经行为的影响

• 批准号: 6303350
• 负责人: DAVID F DINGES
• 金额: $ 2.51万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303350
• 关键词: behavioral /social science research tag; clinical research; cognition; human subject; mood disorders; neuropsychological tests; performance; psychobiology; sleep deprivation; wakefulness

This project seeks to determine how waking neurobehavioral functions (sleep propensity, cognitive performance, sleepiness, and mood) are affected by partial sleep deprivation (PSD), and the time at which the sleep period occurs. PSD has been identified as a serious public health problem being experienced daily by millions of people as a result of medical, psychiatric, and sleep disorders, as well as social demands (work, family, travel). In addition, due to work and other constraints, people are not only sleeping less, but also at various times across the twenty-four hour day, or at different circadian phases. Although highly prevalent, little scientific work has been done on the duration of sleep, at different circadian phases, and number of days of PSD that will lead to increased sleepiness, involuntary sleep episodes, performance failures--information that is essential to determining the level of PSD that could result in accidents (e.g., motor vehicle). In a preliminary study, we developed a protocol for studying PSD and demonstrated the sensitivity of a set of neurobehavioral measures to sleep restriction over 1 week. Further, we examined the effects of restricting the normal nocturnal sleep period to 4, 6, or 8 hours in duration. This study demonstrated significant reductions in neurobehavioral measures when sleep duration was decreased to either 6 or 4 hours. Utilizing this approach, a randomized control trial using independent groups was initiated to test the effects on waking function of the types of sleep restriction most commonly experienced by people, at various times across the twenty-four hour day. The purpose of this study is to determine the nature of the cumulative waking changes in neurobehavioral functions engendered by restricting sleep to 4 h, 6 h, and 8 h (control) per night for 10 consecutive nights, when the sleep loss is placed at different circadian phases. Following a 7-14 day period at home, during which time the subjects are monitored to ensure they have a stable sleep/wake cycle, subjects will live in the Inpatient Study Unit of the CRC for 15 consecutive nights (16 days), during which time their sleep and waking neurobehavioral functions are monitored. Following 2 baseline days of 8h sleep/night, subjects will be randomly assigned to one of the nine sleep restriction conditions (4,6, 8 h/24 hours, with waking occurring at 0330h, 1130h or 1930h) for the next 10 days, followed by 2 days of recovery sleep (10 h/night). Changes in sleep polysomnography and waking neurobehavioral functions at different circadian phases across the 10 day period of sleep restriction are compared among the nine groups.

该项目旨在确定部分睡眠剥夺（PSD）如何影响清醒的神经行为功能（睡眠倾向，认知表现，嗜睡和情绪），以及睡眠期发生的时间。 PSD被认为是一个严重的公共卫生问题，每天都有数百万人因医疗、精神和睡眠障碍以及社会需求（工作、家庭、旅行）而经历。 此外，由于工作和其他限制，人们不仅睡眠减少，而且在24小时内的不同时间，或在不同的昼夜节律阶段。 虽然非常普遍，但关于睡眠持续时间、不同昼夜节律阶段和PSD天数的科学工作很少，这些睡眠持续时间和PSD天数将导致嗜睡增加、非自愿睡眠发作、表现失败--这些信息对于确定可能导致事故的PSD水平是必不可少的（例如，机动车）。 在一项初步研究中，我们开发了一个研究PSD的协议，并证明了一组神经行为措施的敏感性，睡眠限制超过1周。 此外，我们还研究了将正常夜间睡眠时间限制为4、6或8小时的影响。 这项研究表明，当睡眠时间减少到6小时或4小时时，神经行为指标显着降低。 利用这种方法，开始了一项使用独立组的随机对照试验，以测试人们在24小时内不同时间最常经历的睡眠限制类型对清醒功能的影响。 本研究的目的是确定连续10个晚上限制睡眠至每晚4小时、6小时和8小时（对照），当睡眠丧失处于不同的昼夜节律时，所产生的神经行为功能的累积清醒变化的性质。 在7-14天的居家期间，监测受试者以确保其具有稳定的睡眠/觉醒周期，之后受试者将在CRC的住院研究单位连续居住15晚（16天），在此期间监测其睡眠和清醒神经行为功能。 在2个8小时睡眠/夜的基线日之后，受试者将在接下来的10天中被随机分配到9种睡眠限制条件之一（4、6、8小时/24小时，在03：30、11：30或19：30醒来），随后是2天的恢复睡眠（10小时/夜）。 比较9组在10天睡眠限制期间不同昼夜节律时相的睡眠多导睡眠图和清醒神经行为功能的变化。