Symptomatic Hand OA in Chinese and Caucasians

描述(申请人提供)：年疾病流行病学研究 不同的种族群体在疾病方面经常表现出重大差异。 发生了。这些观察结果往往提供了第一批重要线索 疾病病因学。在过去的几十年里，关于种族差异的证据 在放射学的流行中，骨关节炎(OA)已经积累。几个 研究还发现，症状性骨性关节炎的流行，主要发生在髋关节和膝盖 关节，在不同的种族群体中有所不同，但相对较少的研究 在他们的设计中纳入了对症状性疾病的评估，即使 症状性疾病具有公共卫生和临床重要性。致我们的 知识方面，还没有进行基于人群的研究来评估差异 在不同种族人群中有症状的手性骨性关节炎。总的目标是 本研究旨在比较症状性手部骨性关节炎的患病率、手部骨性关节炎的类型 关节受累及其对上肢功能受限的影响 使用从两项基于人口的研究收集的数据，即 Framingham骨关节炎研究和北京骨关节炎研究。我们会 分析从Framingham收集的1099名受试者的数据 骨关节炎研究和来自北京骨关节炎研究的2500名受试者。 这两项研究使用相同的方案来获取和读取手部 X光片，以及评估手部症状和功能的相同问卷 限制。所有信息，包括手部X光读数、手部症状、握力 力量和功能限制已经收集起来了。校长 调查员一直积极参与这两项研究，并发挥了 在研究设计、操作和数据分析中发挥重要作用。结果是 这项研究将产生关于描述流行病学的重要信息 不同种族之间的症状性手性骨性关节炎。首先，这是第一次 在其设计中纳入标准化和统一评估的研究 有症状的手部骨关节炎的患病率，因此有效的比较 中国人和高加索人是可以制造的。其次，两项研究的参与者都是 从人群中随机选择，因此，患病率的差异，联合 症状性手性骨性关节炎受累模式更可能归因于 两个种族之间的遗传和/或环境因素，而不是 抽样偏差；最后，这项研究将检验 两个种族的症状性手性骨性关节炎与上肢功能受限 这样我们就能够估计和比较这一现象的影响 老年人中的功能受限疾病。

DESCRIPTION (provided by applicant): Epidemiologic studies of disease in different racial groups have frequently revealed major difference in disease occurrence. These observations often provide the first important clues to disease etiology. Over the last several decades, evidence on racial difference in the prevalence of radiographic osteoarthritis (OA) has accumulated. Several studies also found that prevalence of symptomatic OA, mainly in hip and knee joints, varies among different racial groups, yet relatively few studies have incorporated an evaluation of symptomatic disease in their design, even though symptomatic disease has public health and clinical importance. To our knowledge, no population-based study has been conducted to assess differences in symptomatic hand OA among different racial groups. The overall objective of this study is to compare the prevalence of symptomatic hand OA, the pattern of joint involvement, and its impact on upper extremity functional limitations using the data collected from two population-based studies, i.e., the Framingham Osteoarthritis Study and the Beijing Osteoarthritis Study. We will analyze the data collected from 1,099 subjects from the Framingham Osteoarthritis Study and 2,500 subjects from the Beijing Osteoarthritis Study. These two studies used identical protocols to obtain and read the hand radiographs, and identical questionnaire to assess hand symptoms and functional limitations. All information, including hand x-ray reading, hand symptoms, grip strength, and functional limitation, has been collected. The principal investigator has been actively involved in both studies, and played an important role in the study design, operation and data analysis. The results of this study will generate important information on the descriptive epidemiology of symptomatic hand OA among different racial groups. First, this is the first study that incorporated into its design a standardized and identical evaluation of the prevalence of symptomatic hand OA so that valid comparisons between Chinese and Caucasians can be made. Second, participants in both studies were randomly selected from the population, thus, difference in prevalence, joint involvement pattern of symptomatic hand OA are more likely attributable to genetic and/or environment factors between two racial groups rather than to sampling bias; Finally, the study will examine the association between symptomatic hand OA and upper extremity functional limitation in two racial groups so that we will be able to estimate and compare the impact of this disease on functional limitation among the elderly.