TENDON TO BONE HEALING--ROLE OF MECHANICAL ENVIRONMENT

描述(由申请人提供)：本研究的总体目标是 肩部正常冈上肌腱附着点的研究 以及它在一定范围内恢复到骨骼插入的能力 在活体动物模型中控制机械环境。一知半解 目前存在于自然修复过程中的插入部位后 手术修复，因此，几乎不能做什么来改善组织的 治愈的能力。在临床上，虽然术后活动的作用 协议没有被很好地理解，它被认为极大地影响了 愈合组织。为了准确地控制活动水平和 定量评估修复后的愈合组织，动物模型是 这是必要的。来自康复反应的可靠和受控的信息 动物模型不仅将提供有关机械本质的基本信息 ，但也可能开始提供关于 适当的术后康复方案，例如，遵循 肩袖修复。生物力学、生物和组织学技术 在我们的实验室中建立将允许严格和定量的 评估愈合组织及其反应机制。肌腱 植入骨头的手术将受到损伤和修复，并受到 不同的术后活动水平。我们的全球假设是在活体内 机械因素(运动、笼子活动和固定)将导致 在机械性能、组成和组织方面的变化 正在修复插入部位。

DESCRIPTION (provided by applicant): The overall objective of this study is to investigate the normal supraspinatus tendon insertion site in the shoulder as well as its ability to heal back to its bony insertion under a range of controlled mechanical environments in an in vivo animal model. Little knowledge currently exists on the natural repair process of the insertion site after surgical repair, and as a result, little can be done to improve the tissue's ability to heal. Clinically, while the role of the post operative activity protocol is not well understood, it is believed to greatly influence the healing tissue. In order to accurately control the activity level and to quantitatively assess the healing tissue following repair, an animal model is necessary. Reliable and controlled information from the healing response in the animal model will not only provide basic information on the mechanistic nature of this healing process, but might also begin to provide insight regarding an appropriate post-operative rehabilitation protocol following, for example, a rotator cuff repair. Biomechanical, biologic, and histologic techniques established in our laboratories will allow for a rigorous and quantitative assessment of the healing tissue and the mechanisms of its response. Tendon insertions to bone will be surgically injured and repaired and subjected to various post operative activity levels. Our global hypothesis is that in vivo mechanical factors (exercise vs. cage activity vs. immobilization) will cause a change in the mechanical properties, composition, and organization of the healing insertion site.