TENDON TO BONE HEALING--ROLE OF MECHANICAL ENVIRONMENT

肌腱到骨骼的愈合——机械环境的作用

• 批准号: 6632805
• 负责人: GERALD R WILLIAMS
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6632805
• 关键词: biomechanics; bone; functional ability; in situ hybridization; laboratory rat; light microscopy; mathematical model; mechanical stress; musculoskeletal injury; postoperative complications; statistics /biometry; tendon injury; viscosity; wound healing

DESCRIPTION (provided by applicant): The overall objective of this study is to investigate the normal supraspinatus tendon insertion site in the shoulder as well as its ability to heal back to its bony insertion under a range of controlled mechanical environments in an in vivo animal model. Little knowledge currently exists on the natural repair process of the insertion site after surgical repair, and as a result, little can be done to improve the tissue's ability to heal. Clinically, while the role of the post operative activity protocol is not well understood, it is believed to greatly influence the healing tissue. In order to accurately control the activity level and to quantitatively assess the healing tissue following repair, an animal model is necessary. Reliable and controlled information from the healing response in the animal model will not only provide basic information on the mechanistic nature of this healing process, but might also begin to provide insight regarding an appropriate post-operative rehabilitation protocol following, for example, a rotator cuff repair. Biomechanical, biologic, and histologic techniques established in our laboratories will allow for a rigorous and quantitative assessment of the healing tissue and the mechanisms of its response. Tendon insertions to bone will be surgically injured and repaired and subjected to various post operative activity levels. Our global hypothesis is that in vivo mechanical factors (exercise vs. cage activity vs. immobilization) will cause a change in the mechanical properties, composition, and organization of the healing insertion site.

描述（由申请方提供）：本研究的总体目标是 研究肩部正常冈上肌腱止点， 以及其在一定范围内恢复其骨插入的能力， 在体内动物模型中的受控机械环境。小知识 目前存在于插入部位的自然修复过程中， 手术修复，因此，几乎无法改善组织的 治愈的能力。临床上，虽然术后活动的作用 协议没有得到很好的理解，它被认为是极大地影响了 愈合组织为了准确地控制活动水平， 为了定量评估修复后的愈合组织， 必要从治疗反应中获得的可靠和受控的信息 动物模型不仅提供了关于机械性质的基本信息， 但也可能开始提供关于 适当的术后康复方案，例如， 肩袖修复术生物力学、生物学和组织学技术 在我们的实验室建立将允许一个严格的和定量的 评估愈合组织及其反应机制。肌腱 插入骨将手术损伤和修复，并受到 各种术后活动水平。我们的总体假设是， 机械因素（运动vs.笼活动vs.固定）将导致 机械性能、组成和组织的变化 愈合插入部位。