MECHANISMS OF IMMUNOPATHOLOGY IN DHF/DSS

DHF/DSS 的免疫病理学机制

• 批准号: 6341632
• 负责人: FRANCIS ANTHONY ENNIS
• 金额: $ 104.76万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6341632
• 关键词: dengue; dengue virus; immunopathology

The goal of this program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections. The frequency of DHF/DSS is much greater during secondary infections with dengue virus strains of a different dengue serotype than that which caused the primary infection. These immunopathological results have slowed down vaccine development because of safety concerns. The morbidity and mortality associated with severe dengue infections is a major public health problem which is increasing in frequency. We propose to define the molecular and cellular basis of the immunopathology associated with severe dengue infections.

该项目的目标是了解免疫病理学 登革出血热（DHF）和登革休克综合征（DSS）， 登革热病毒感染的严重并发症。 的频率 DHF/DSS在登革热病毒继发感染期间要大得多 不同的登革热血清型的菌株，而不是引起 原发性感染这些免疫病理学结果已经减缓了 疫苗研发出于安全考虑。的发病率和 与严重登革热感染相关的死亡率是一个主要的公众 健康问题日益频繁。我们建议定义 与之相关的免疫病理学的分子和细胞基础 严重的登革热感染。