GENETICS OF LOW DOSE ETHANOL EFFECTS

低剂量乙醇效应的遗传学

• 批准号: 6371635
• 负责人: RICHARD A DEITRICH
• 金额: $ 15.1万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6371635
• 关键词: alcoholism /alcohol abuse; animal colony; behavioral /social science research tag; behavioral genetics; disease /disorder model; ethanol; genetic susceptibility; laboratory rat; neurogenetics; neuropharmacology; quantitative trait loci

Among the risk factors for alcoholism in humans is a low initial sensitivity and/or a rapid development of tolerance to ethanol. These behavioral reactions can be modeled in animals. One such model is Alcohol Tolerant (AT) and Alcohol Non-Tolerant (ANT) lines of rats that were selectively bred for genetic tolerance to a low, ataxic dose of ethanol. These animals have been transferred to the University of Colorado and we will compare the genetic characteristics of these animals with those that we have selectively bred to genetic tolerance to a high, anesthestizing dose of ethanol, the High Alcohol Sensitive (HAS) and Low Alcohol Sensitive (LAS) rats. We will locate and compare Quantitiative Trait Loci in these two groups of animals as well as carry out comparisons on the development of tolerance to a number of behavioral effects of ethanol. In addition we will make the AT and ANT rats available to researchers in this country and abroad for their studies. The data generated along with similar data from studies in mice will be useful in the search for the genes that underlie the risk factors for alcoholism in humans.

人类酒精中毒的风险因素之一是对乙醇的低初始敏感性和/或耐受性的快速发展。这些行为反应可以在动物身上模仿。一种这样的模型是酒精耐受（AT）和酒精非耐受（ANT）系的大鼠，其被选择性地繁殖以对低的共济失调剂量的乙醇的遗传耐受。这些动物已被转移到科罗拉多大学，我们将比较这些动物的遗传特征与那些我们选择性繁殖的对高麻醉剂量乙醇的遗传耐受性，高酒精敏感性（HAS）和低酒精敏感性（LAS）大鼠。我们将在这两组动物中定位和比较定量性状基因座，并对乙醇的一些行为效应的耐受性发展进行比较。此外，我们将使AT和ANT大鼠提供给国内外的研究人员进行研究。这些数据沿着来自小鼠研究的类似数据将有助于寻找人类酗酒风险因素的基因。