ROLE OF ACETALDEHYDE IN CENTRAL ACTIONS OF ETHANOL

产品说明： 第一个特异性的目的是发现和鉴定酶 负责在大脑中将乙醇氧化成乙醛， 小鼠第二个目的是研究积累的机制， 大脑中的乙醛改变了乙醇在中枢神经系统中的作用 系统初步结果提供了乙醇诱导的 催眠（睡眠时间）和大脑乙醛水平。这是一个合作 Sergey Zimatkin博士和他的同事在研究所的项目 生物化学，格罗德诺，白俄罗斯在前苏联和理查德博士 Deitrich和他在大学酒精研究中心的同事们 科罗拉多健康科学中心。格罗德诺生物化学研究所 长期以来一直以研究乙醇的代谢和作用而闻名 并拥有进行必要的生化研究的专业知识 项目动物繁殖和行为测试将在 科罗拉多大学酒精研究中心。该中心有选择地 培育小鼠对乙醇的不同反应， 在这些动物的行为和遗传特征方面的经验。在 此外，我们现在有无丙氨酸转氨酶小鼠以及细胞色素P450 2EI 敲除小鼠由于过氧化氢酶和这种细胞色素都与 乙醇氧化，这些敲除小鼠将特别有用。

DESCRIPTION: The first specific is designed to discover and identify the enzymes responsible for the oxidation of ethanol to acetaldehyde in the brains of mice. The second aim is to study the mechanisms by which the accumulation of acetaldehyde in the brain alters the effect of ethanol in the central nervous system. Preliminary results provide a correlation between ethanol induced hypnosis (sleep time) and brain acetaldehyde levels. It is a collaborative project between Dr. Sergey Zimatkin and his colleagues at the Institute of Biochemistry, Grodno, Belarus in the former Soviet Union and Dr. Richard Deitrich and his colleagues at the Alcohol Research Center at the University of Colorado Health Sciences Center. The Institute of Biochemistry in Grodno has long been known for its studies on the metabolism and actions of ethanol and have the expertise to carry out the biochemical studies necessary for this project. The animal breeding and behavioral tests will be conducted at the University of Colorado Alcohol Research Center. This Center has selectively bred mice for differential responses to ethanol and has a great deal of experience in the behavioral and genetic characterization of such animals. In addition, we now have acatalasemic mice as well as Cytochrome P450 2EI knockout mice. Since both catalase and this cytochrome have been implicated in ethanol oxidation, these knockout mice will be especially useful.