BODY COMPOSITION CHANGES IN THE ELDERLY--SARCOPENIA

老年人身体成分的变化——肌肉减少症

• 批准号: 6371774
• 负责人: RICHARD N. BAUMGARTNER
• 金额: $ 74.83万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6371774
• 关键词: Hispanic Americans; accidental falls; age difference; aging; bioenergetics; body composition; body physical activity; cognition; dehydroepiandrosterone; diet; disease /disorder proneness /risk; estrone; female; functional ability; gender difference; health surveys; hormone regulation /control mechanism; human morbidity; human old age (65+); human subject; insulinlike growth factor; leptin; longitudinal human study; male; muscle disorders; muscle strength; muscle tone; nutrition of aging; nutrition related tag; photon absorptiometry; striated muscles; thyroxine

DESCRIPTION: (Adapted from Investigator's Abstract) The main objectives of this competing continuation application are to develop methods of estimating the prevalence and incidence rates of sarcopenia, or deficient relative muscle mass, and to determine sex and ethnic differences in risk factors and consequences of sarcopenia in community-dwelling elderly. It is accepted that muscle mass and strength are gradually lost with age. Because there are few methods of quantifying muscle mass in population studies, and criteria for defining "deficient" muscle mass remain to be established, estimates of the prevalence and incidence of sarcopenia are lacking and the extent of the public health problem posed is unknown. Age-related loss of muscle mass is undoubtedly multifactorial. Although a variety of possible mechanisms and etiological factors have been indicated, there are few data for multivariate associations of risk factors with sarcopenia. Sarcopenia is believed to be a major factor associated with physical functional impairment, and a number of studies have reported that indicators of muscle strength and function (e.g., balance, gait speed, etc.) are associated with disability and falls in elderly people. There are few reports, however, for direct associations between sarcopenia and disability or falls. Sex and ethnic differences in rates of loss for muscles mass and strength, risk factors and consequences remain to be established. The proposed study will establish methods for defining sarcopenia using cross-sectional data collected previously in the New Mexico Elder Health Survey (NMEHS, 1993-1996, n = 883) and reference data to be collected for a population-based sample of 300 young adults 20 to 40 years of age. Risk factors and long-term consequences of sarcopenia will be studied using 4 to 10 years of follow up data by continuation of the New Mexico Aging Process Study (NMAPS, current n = 404). The following variables have been measured in the NMAPS since 1993: muscle mass from dual-energy X-ray absorptiometry, serum nutrient and hormone levels (e.g. free-T, estrone, IGF1, DHEAs, leptin), dietary intake, physical activity and resting energy expenditure, cognitive and physical functional status, disability, incident falls and morbidity. Data collected for these variables will be extended another 5 years. The NMEHS included Hispanic elderly men and women: 200 new Hispanic participants will be recruited in the NMAPS to further facilitate ethnic comparisons for risk factors and consequences of sarcopenia.

描述：（改编自研究者摘要）主要目的 这个竞争性的延续应用程序是开发估算方法， 肌肉减少症或缺乏亲属患病率和发病率 肌肉质量，并确定风险因素的性别和种族差异， 社区老年人肌肉减少症的后果。 它被接受 肌肉质量和力量会随着年龄的增长而逐渐丧失。 因为 在人口研究中，很少有量化肌肉质量的方法， 定义“缺乏”肌肉质量的标准仍有待建立， 缺乏对肌肉减少症的患病率和发病率的估计， 所造成的公共卫生问题的严重程度尚不清楚。 与索赔有关的损失 肌肉质量无疑是多因素的。 尽管有各种可能的 机制和病因已指出，有很少的数据 风险因素与肌肉减少症的多变量关联。 肌肉减少 被认为是与身体功能相关的主要因素 损伤，许多研究报告称，肌肉指标 强度和功能（例如，平衡、步态速度等）关联 残疾和老年人的福尔斯。 然而，很少有报道称， 肌肉减少症和残疾或福尔斯之间的直接联系。 性别和 肌肉质量和力量、风险损失率的种族差异 因素和后果尚待确定。 拟议的研究将建立定义肌肉减少症的方法， 以前在新墨西哥州老年健康中心收集的横断面数据 调查（NMEHS，1993-1996年，n = 883）和参考数据， 300名20至40岁的年轻人的基于人口的样本。 风险 将使用4至10个月的时间研究肌肉减少症的因素和长期后果。 通过继续新墨西哥州老化过程获得的10年随访数据 研究（NMAPS，当前n = 404）。 已测量了以下变量 自1993年以来的NMAPS：双能X射线吸收测定法的肌肉质量， 血清营养素和激素水平（例如游离T、雌酮、IGF 1、DHEA， 瘦素）、饮食摄入、体力活动和静息能量消耗， 认知和身体功能状态、残疾、意外福尔斯和 发病率 为这些变量收集的数据将再延长5 年 NMEHS包括西班牙裔老年男性和女性：200名新的西班牙裔 参与者将在NMAPS招募，以进一步促进种族 比较肌肉减少症的风险因素和后果。