BODY COMPOSITION CHANGES IN THE ELDERLY--SARCOPENIA

描述：(改编自《调查员摘要》)主要目标 这一竞争的延续应用程序是为了开发估计方法 骨质疏松症的患病率和发病率，或缺乏亲属 肌肉质量，并确定性别和种族差异的危险因素和 社区老年人骨质疏松症的后果。它被接受了 随着年龄的增长，肌肉质量和力量会逐渐丧失。因为在那里 在人群研究中，很少有量化肌肉质量的方法，而且 定义“缺陷”肌肉质量的标准仍有待建立， 缺乏对石棺减少的患病率和发病率的估计， 造成的公共卫生问题的程度尚不清楚。与年龄相关的损失 肌肉质量无疑是多因素的。尽管有多种可能的 发病机制和致病因素已被揭示，但资料较少。 以了解危险因素与石棺减少症的多变量关联。石棺减少症 被认为是与身体机能相关的一个主要因素 损伤，一些研究报告说，肌肉的指标 力量和功能(例如，平衡、步态速度等)与以下内容关联 老年人中的残疾和跌倒。然而，很少有关于 骨质疏松症与残疾或跌倒之间存在直接联系。性爱和 肌肉质量、力量、风险损失率的种族差异 影响因素和后果尚待确定。 拟议的研究将建立定义石棺减少的方法，使用 先前在《新墨西哥州老年人健康》杂志上收集的横断面数据 调查(NMEHS，1993-1996，n=883)和将收集的参考数据 以人口为基础的样本为300名20至40岁的年轻人。风险 骨质疏松症的因素和长期后果将使用4到 新墨西哥州老龄化进程延续的10年跟踪数据 研究(NMAP，当前n=404)。测量了以下变量 自1993年以来在NMAPs中：来自双能X射线吸收测量法的肌肉质量， 血清营养和激素水平(如游离T、雌酮、IGF1、dheas、 瘦素)、饮食摄入量、体力活动和静息能量消耗， 认知和身体功能状态、残疾、事故跌倒和 发病率。为这些变量收集的数据将再延长5 好几年了。NMEHS包括西班牙裔老年男性和女性：200名新拉美裔 将在国家行动计划中招募参与者，以进一步促进 石棺减少的危险因素和后果的比较。

DESCRIPTION: (Adapted from Investigator's Abstract) The main objectives of this competing continuation application are to develop methods of estimating the prevalence and incidence rates of sarcopenia, or deficient relative muscle mass, and to determine sex and ethnic differences in risk factors and consequences of sarcopenia in community-dwelling elderly. It is accepted that muscle mass and strength are gradually lost with age. Because there are few methods of quantifying muscle mass in population studies, and criteria for defining "deficient" muscle mass remain to be established, estimates of the prevalence and incidence of sarcopenia are lacking and the extent of the public health problem posed is unknown. Age-related loss of muscle mass is undoubtedly multifactorial. Although a variety of possible mechanisms and etiological factors have been indicated, there are few data for multivariate associations of risk factors with sarcopenia. Sarcopenia is believed to be a major factor associated with physical functional impairment, and a number of studies have reported that indicators of muscle strength and function (e.g., balance, gait speed, etc.) are associated with disability and falls in elderly people. There are few reports, however, for direct associations between sarcopenia and disability or falls. Sex and ethnic differences in rates of loss for muscles mass and strength, risk factors and consequences remain to be established. The proposed study will establish methods for defining sarcopenia using cross-sectional data collected previously in the New Mexico Elder Health Survey (NMEHS, 1993-1996, n = 883) and reference data to be collected for a population-based sample of 300 young adults 20 to 40 years of age. Risk factors and long-term consequences of sarcopenia will be studied using 4 to 10 years of follow up data by continuation of the New Mexico Aging Process Study (NMAPS, current n = 404). The following variables have been measured in the NMAPS since 1993: muscle mass from dual-energy X-ray absorptiometry, serum nutrient and hormone levels (e.g. free-T, estrone, IGF1, DHEAs, leptin), dietary intake, physical activity and resting energy expenditure, cognitive and physical functional status, disability, incident falls and morbidity. Data collected for these variables will be extended another 5 years. The NMEHS included Hispanic elderly men and women: 200 new Hispanic participants will be recruited in the NMAPS to further facilitate ethnic comparisons for risk factors and consequences of sarcopenia.