BODY COMPOSITION CHANGES IN THE ELDERLY--SARCOPENIA

老年人身体成分的变化——肌肉减少症

• 批准号: 6509563
• 负责人: RICHARD N. BAUMGARTNER
• 金额: $ 77.04万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509563
• 关键词: Hispanic Americans; accidental falls; age difference; aging; bioenergetics; body composition; body physical activity; cognition; dehydroepiandrosterone; diet; disease /disorder proneness /risk; estrone; female; functional ability; gender difference; health surveys; hormone regulation /control mechanism; human morbidity; human old age (65+); human subject; insulinlike growth factor; leptin; longitudinal human study; male; muscle disorders; muscle strength; muscle tone; nutrition of aging; nutrition related tag; photon absorptiometry; striated muscles; thyroxine

DESCRIPTION: (Adapted from Investigator's Abstract) The main objectives of this competing continuation application are to develop methods of estimating the prevalence and incidence rates of sarcopenia, or deficient relative muscle mass, and to determine sex and ethnic differences in risk factors and consequences of sarcopenia in community-dwelling elderly. It is accepted that muscle mass and strength are gradually lost with age. Because there are few methods of quantifying muscle mass in population studies, and criteria for defining "deficient" muscle mass remain to be established, estimates of the prevalence and incidence of sarcopenia are lacking and the extent of the public health problem posed is unknown. Age-related loss of muscle mass is undoubtedly multifactorial. Although a variety of possible mechanisms and etiological factors have been indicated, there are few data for multivariate associations of risk factors with sarcopenia. Sarcopenia is believed to be a major factor associated with physical functional impairment, and a number of studies have reported that indicators of muscle strength and function (e.g., balance, gait speed, etc.) are associated with disability and falls in elderly people. There are few reports, however, for direct associations between sarcopenia and disability or falls. Sex and ethnic differences in rates of loss for muscles mass and strength, risk factors and consequences remain to be established. The proposed study will establish methods for defining sarcopenia using cross-sectional data collected previously in the New Mexico Elder Health Survey (NMEHS, 1993-1996, n = 883) and reference data to be collected for a population-based sample of 300 young adults 20 to 40 years of age. Risk factors and long-term consequences of sarcopenia will be studied using 4 to 10 years of follow up data by continuation of the New Mexico Aging Process Study (NMAPS, current n = 404). The following variables have been measured in the NMAPS since 1993: muscle mass from dual-energy X-ray absorptiometry, serum nutrient and hormone levels (e.g. free-T, estrone, IGF1, DHEAs, leptin), dietary intake, physical activity and resting energy expenditure, cognitive and physical functional status, disability, incident falls and morbidity. Data collected for these variables will be extended another 5 years. The NMEHS included Hispanic elderly men and women: 200 new Hispanic participants will be recruited in the NMAPS to further facilitate ethnic comparisons for risk factors and consequences of sarcopenia.

描述：（改编自研究者摘要）的主要目标

项目成果

Behaviors underlying the use of nonvitamin nonmineral dietary supplements in a healthy elderly cohort.

健康老年人群中使用非维生素非矿物质膳食补充剂的行为。

• 发表时间: 2007
• 期刊: The journal of nutrition, health & aging
• 作者: Wold,RS;Wayne,SJ;Waters,DL;Baumgartner,RN
• 通讯作者: Baumgartner,RN

Increasing trends in elderly persons' use of nonvitamin, nonmineral dietary supplements and concurrent use of medications.

• DOI: 10.1016/j.jada.2004.11.002
• 发表时间: 2005
• 期刊: Journal of the American Dietetic Association
• 作者: R. Wold;S. Lopez;C. L. Yau;L. Butler;S. Pareo-Tubbeh;D. Waters;P. Garry;R. Baumgartner

Serum leptin levels, bone mineral density and osteoblast alkaline phosphatase activity in elderly men and women.

老年男性和女性的血清瘦素水平、骨矿物质密度和成骨细胞碱性磷酸酶活性。

• DOI: 10.1016/s0047-6374(02)00195-1
• 发表时间: 2003
• 期刊: Mechanisms of ageing and development
• 影响因子: 5.3
• 作者: Scariano,JohnK;Garry,PhilipJ;Montoya,GeorgeD;Chandani,AliK;Wilson,JaniceM;Baumgartner,RichardN
• 通讯作者: Baumgartner,RichardN

Serum insulin concentrations in daily drinkers compared with abstainers in the New Mexico elder health survey.

新墨西哥州老年人健康调查中，每日饮酒者与戒酒者的血清胰岛素浓度进行了比较。

• DOI: 10.1093/gerona/58.10.m960
• 发表时间: 2003
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Kenkre,PrabhavV;Lindeman,RobertD;LillianYau,C;Baumgartner,RichardN;Garry,PhilipJ
• 通讯作者: Garry,PhilipJ

Mitochondrial function in physically active elders with sarcopenia.

患有肌肉减少症的体力活动老年人的线粒体功能。

• DOI: 10.1016/j.mad.2009.01.006
• 发表时间: 2009
• 期刊: Mechanisms of ageing and development
• 影响因子: 5.3
• 作者: Waters,DL;Mullins,PG;Qualls,CR;Raj,DSC;Gasparovic,C;Baumgartner,RN
• 通讯作者: Baumgartner,RN