IMAGING BRAIN MATURATION AND NEUROBEHAVIORAL CORRELATES

大脑成熟成像和神经行为相关性

• 批准号: 6391431
• 负责人: ELIZABETH R SOWELL
• 金额: $ 11.13万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-02 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6391431
• 关键词: adolescence (12-20); bioimaging /biomedical imaging; brain imaging /visualization /scanning; child (0-11); clinical research; cognition; developmental neurobiology; functional magnetic resonance imaging; human subject; learning; magnetic resonance imaging; memory; neuroanatomy; psychological tests

The primary objectives of this proposal are to localized and stage structural maturational brain changes between childhood and adolescence using structural magnetic resonance imaging (sMRI), and to relate these brain changes to improving cognitive abilities assessed with cognitive psychological tests of learning and memory and functioning MRI (fMRI). Neurodevelopment in normal children and adolescents is not yet well understood, but the few studies in the literature that have focused on this topic have shown regionally specific age-related changes in brain morphology. These maturational changes are characterized by great variability between individuals, even within narrow chronological age ranges. Such variability is also found in normative studies of improving cognitive abilities, and correlations have been found between cognitive measures and some brain measures. Notably, these relationships do not tend to be mediated by age, suggesting that maturational factors that are not well indexed by chronological age are involved with the plasticity in brain structure and its neurobehavioral correlates. The increased understanding of normal brain development obtained through this proposed program of research will be useful in scientific endeavors to understand aberrant brain maturation and cognitive impairments in children with various neurodevelopmental disorders, understand aberrant brain maturation and cognitive impairments in children with various neurodevelopmental disorders. This proposal details a plan for didactic study, enabling the candidate to acquire new skills in acquisition and analysis of sMRI and fMRI data, with supervised research to address the following specific aims: (1) To analyze existing high resolution imaging data from 300 normal children and adolescents by adapting measurement tools that will provide localized information about structural change throughout development. (2) To categorize individuals based on sMRI data in such a way to enable reasonable comparisons across developmental stages. It is hypothesized that chronological age will only roughly correlate with groups of subjects that are categorized by patterns of changing brain structure. (3) To investigate neurobehavioral correlates of brain maturation in a small prospective study using sMRI, and modern cognitive psychological tests for detailed assessment of learning and memory abilities. (4) To assess neurobehavioral assessment. It is hypothesized that dissociative brain regions will be involved in distinct cognitive functions (e.g., verbal memory vs. spatial memory), and similar brain regions will be implicated in the fMRI studies of memory, and the sMRI/memory correlation studies.

该提案的主要目标是利用结构磁共振成像（sMRI）对儿童期和青春期之间的大脑结构成熟变化进行局部和分阶段，并将这些大脑变化与通过学习和记忆认知心理测试以及功能磁共振成像（fMRI）评估的认知能力的提高联系起来。正常儿童和青少年的神经发育尚不清楚，但文献中关注这一主题的少数研究表明，大脑形态存在区域特定的年龄相关变化。这些成熟变化的特点是个体之间存在巨大差异，即使在狭窄的实际年龄范围内也是如此。在提高认知能力的规范研究中也发现了这种变异性，并且在认知测量和某些大脑测量之间发现了相关性。值得注意的是，这些关系往往不是由年龄介导的，这表明不能通过实际年龄很好地索引的成熟因素与大脑结构的可塑性及其神经行为相关性有关。通过这项拟议的研究计划获得的对正常大脑发育的更多了解将有助于科学努力，以了解患有各种神经发育障碍的儿童的异常大脑成熟和认知障碍，了解患有各种神经发育障碍的儿童的异常大脑成熟和认知障碍。该提案详细介绍了教学研究计划，使候选人能够获得获取和分析 sMRI 和 fMRI 数据的新技能，并通过监督研究来解决以下具体目标：（1）通过调整测量工具来分析来自 300 名正常儿童和青少年的现有高分辨率成像数据，这些工具将提供有关整个发育过程中结构变化的本地化信息。 (2) 根据 sMRI 数据对个体进行分类，以便能够在各个发育阶段进行合理比较。据推测，实际年龄仅与按大脑结构变化模式分类的受试者群体大致相关。 (3) 在一项小型前瞻性研究中，使用 sMRI 和现代认知心理测试来调查大脑成熟的神经行为相关性，以详细评估学习和记忆能力。 (4) 评估神经行为评估。据推测，分离的大脑区域将涉及不同的认知功能（例如，言语记忆与空间记忆），并且类似的大脑区域将涉及记忆的 fMRI 研究和 sMRI/记忆相关性研究。