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Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence

青春期大脑、神经认知和青春期成熟的成像

基本信息

批准号：
8511826
负责人：
ELIZABETH R SOWELL
金额：
$ 62.87万
依托单位：
CHILDREN'S HOSPITAL OF LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-21 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8511826
关键词：
15 year old Address Adolescence Adolescent Adult Affect Affective Age Amygdaloid structure Animals Anisotropy Anxiety Behavior Behavioral Bilateral Brain Brain imaging Brain region Cell physiology Child Childhood Cognition Cognitive Competence Data Depressed mood Depression and Suicide Development Diffusion Magnetic Resonance Imaging Dissociation Dorsal Emotional Emotions Environmental Risk Factor Equilibrium Estrogens Face Face Processing Facial Expression Female Fiber Functional Imaging Functional Magnetic Resonance Imaging Gender Genetic Goals Gonadal Steroid Hormones Hippocampus (Brain)Hormonal Hormones Human Hydrocortisone Image Analysis Impulsivity Individual Inferior Lateral Left Literature Magnetic Resonance Imaging Maps Measures Medial Mediating Mediation Mental Health Mental disorders Modeling Motivation Multimodal Imaging NIH Program Announcements National Institute of Mental Health Neurocognitive Neurosecretory Systems Occipital lobe Outcome Parietal Lobe Participant Pattern Performance Phase Prefrontal Cortex Process Psychopathology Puberty Radial Relative (related person)Reporting Research Research Personnel Rewards Risk Risk Assessment Saliva Sampling Scanning Sex Characteristics Sexual Maturation Signal Transduction Social Change Social Functioning Social Interaction Staging Stress Structure Study Subject Substance abuse problem Synapses System Task Performances Temporal Lobe Testing Testosterone Thick Time Visual Work Youth age effect age related analog area striata association cortex base behavior test boys brain behavior cognitive control cognitive function dehydroepiandrosterone density diaries discounting executive function frontal lobe frontal lobe cortex functional status girls gray matter improved indexing interest male multidisciplinary myelination neurocognitive test neuroimaging public health relevance relating to nervous system response reward processing sex standardize measure white matter

项目摘要

DESCRIPTION (provided by applicant): Enormous progress has been made recently in understanding the age-related structural maturational changes that occur in the human brain during childhood and adolescence, but variability in brain structure is very large, even among individuals of the same chronological age. The literature suggests an offset in development of limbic structures which control affect, emotion, encoding information, which may develop prior to the executive centers (frontal cortices) that provide regulatory control over impulses and risk assessment. Almost nothing is yet known about neurodevelopmental, neuroendocrine, behavioral and environmental factors that likely relate to variability in brain structure and function, and cognitive abilities that change so dramatically during adolescence. In this project, we propose to longitudinally study 120 typically developing adolescents between 9 and 15 years of age with 2-year scan intervals, and to collect brain imaging (structural MRI, diffusion tensor imaging and functional MRI with tasks of response inhibition, reward processing, delayed discounting, facial affect processing), neurocognitive (with emphasis on executive functioning and cognitive control), physical sexual maturation (using Tanners staging), and hormonal (cortisol, testosterone, estrogen and Dehydroepiandrosterone (DHEA) using saliva samples) data as well as measures of daily stress. With these rich multimodal imaging, behavioral, cognitive and hormonal data, we will address the following specific aims: 1) to distinguish hormone-dependent from non-hormone dependent neurodevelopmental effects in adolescence, 2) to evaluate relationships between brain changes and behavioral indices of cognition (cognitive control, executive functions, daily stress) and motivation (e.g., reward sensitivity), and 3) to evaluate gender differences in relationships between brain changes and indices of pubertal progression. To our knowledge, this will be the first study to undertake such challenges by using cutting-edge integrative multimodal image analyses of functional and structural MRI to examine, longitudinally, brain development in adolescents and to distinguish hormonal from other age-related environmental and behavioral correlates.

描述（由申请人提供）：最近在理解儿童期和青春期人类大脑中发生的与年龄相关的结构成熟变化方面取得了巨大进展，但大脑结构的变异性非常大，即使在相同实足年龄的个体中也是如此。文献表明，控制情感、情绪、编码信息的边缘系统结构的发展存在偏移，这些结构可能先于执行中心（额叶皮质）发展，执行中心提供对冲动和风险评估的调节控制。关于可能与大脑结构和功能的变化有关的神经发育、神经内分泌、行为和环境因素，以及在青春期发生如此巨大变化的认知能力，几乎一无所知。本研究拟对120名9 ~ 15岁发育正常的青少年进行为期2年的脑扫描，并收集其脑影像资料（结构MRI、扩散张量成像和功能MRI，具有反应抑制、奖励处理、延迟折扣、面部情感处理任务）、神经认知（重点是执行功能和认知控制）、身体性成熟（使用Tendon分期）和激素（使用唾液样本的皮质醇、睾酮、雌激素和脱氢表雄酮（DHEA））数据以及日常压力的测量。有了这些丰富的多模态成像、行为、认知和激素数据，我们将解决以下具体目标：1）区分青春期的激素依赖性和非激素依赖性神经发育影响，2）评估大脑变化与认知（认知控制、执行功能、日常压力）和动机（例如，奖励敏感性），以及3）评估大脑变化和青春期进展指数之间关系的性别差异。据我们所知，这将是第一项通过使用功能和结构MRI的尖端综合多模态图像分析来接受此类挑战的研究，以纵向检查青少年的大脑发育，并将激素与其他年龄相关的环境和行为相关因素区分开来。