Mentored Investigator Award in Women's Health

描述(申请人提供)：本奖项的目的是提供 支持Lori Boardman博士在以下领域接受正式培训 生物统计学、流行病学和公共卫生，从而达到必要的 进一步发展患者事业的理论和方法背景- 以研究为导向。该奖项的最后三年将致力于 设计、实施、数据分析和编制一个 队列中两种戒烟干预措施的随机对照试验 对帕帕尼科劳异常涂片进行评估的妇女。这个 这项研究的主要目的是评估两国之间的戒烟率 两组，并通过测量以下指标确认自我报告的戒断 宫颈粘液可替宁。次要目标是确定回归 戒烟者与戒烟者宫颈肿瘤率的比较 继续并评估人类的独立和联合贡献 乳头瘤病毒与吸烟对自然病史的不典型或低度影响 宫颈肿瘤(包括细胞学和/或组织学)。这场审判将是 在多学科和经验丰富的团队的指导下进行 包括经验丰富的女性健康和行为健康研究人员， 流行病学家、肿瘤学家和统计学家。 近期职业目标：接受研究设计和培训方面的正式培训 通过获得公共卫生硕士学位进行分析；提高能力 设计、执行、分析和交流研究成果 准备硕士论文和正在进行的研究的正式报告 源于宫颈肿瘤的临床工作；实施和完成一项 两种戒烟干预措施对宫颈鳞癌妇女的随机试验 肿瘤。 长期职业目标：成为妇女保健领域的一名独立和富有成效的调查员；获得独立补助金 资助以患者为中心的研究；成为学术医学的领导者 并指导更多对女性健康感兴趣的初级调查人员。

DESCRIPTION (provided by applicant): The purpose of this award is to provide support for Dr. Lori Boardman to pursue formal training in the fields of biostatistics, epidemiology and public health, thereby attaining the necessary theoretical and methodological background to further a career in patient- oriented research. The final three years of the award will be devoted to the design, implementation, analysis of data and preparation of the results of a randomized controlled trial of two smoking cessation interventions in a cohort of women referred for the evaluation of abnormal Papanicolaou smears. The primary aims of this study are to evaluate smoking cessation rates between the two groups and to confirm self-reports of cessation through measurement of cervical mucus cotinine. The secondary aims are to determine the regression rate of cervical neoplasia in women who quit smoking compared to those who continue and to assess the independent and combined contribution of human papillomavirus and smoking on the natural history of atypical or low-grade cervical neoplasia (includes cytology and/or histology). This trial will be conducted with the guidance of a multidisciplinary and experienced team including experienced women's health and behavioral health researchers, epidemiologists, an oncologist, and a statistician. Immediate Career Objectives: Pursue formal training in research design and analysis by obtaining a master's degree in public health; Improve abilities to design, perform, analyze and communicate research findings through the preparation of a master's thesis and formal presentations of ongoing research stemming from clinical work in cervical neoplasia; Implement and complete a randomized trial of two smoking cessation interventions in women with cervical neoplasia. Lone-Term Career Objectives: Become an independent and productive investigator in the field of women's health care; Secure independent grant funding for patient-oriented research; Become a leader in academic medicine and mentor more junior investigators interested in women's health.