Evaluation of Fiber Biomaterials for Oral Implantology

描述：（由申请人提供）本K23奖申请是基于 根据该候选人的长期目标，设计和进行临床研究 开发新型牙科生物材料应用于临床。候选人是董事会 具有修复学和牙周病学两个临床牙科专业资格。 作为一名住院医师和教职员工，他有机会与 知识渊博的研究人员，他们指导他在以病人为基础的 research.候选人对科学方法有了很好的理解 和坚实的技能基础，但寻求进一步他的研究技能， 获得独立性并更有效地与生物材料合作 研究人员和生物统计学家。一个指导培训计划，其中包括 在临床研究等领域的教学培训的具体领域， 方法学、数据管理、生物统计学和聚合物复合材料科学将 让候选人实现这些目标。 这位候选人近年来的研究重点是 纤维增强复合材料（FRC）研究。该候选人曾参与 开发FRC材料，设计用于牙科的技术， 假体和测试这些材料和技术在实验室和 诊所该提案旨在为FRC假体提供临床测试 用于牙科种植。已经开发了玻璃FRC材料，其具有 制造美观牙科植入体假体下部结构的可能性 没有可能的腐蚀和毒性，这可能会被视为与 常用的金属合金。评价FRC的实验室和临床研究 用于修复和替换牙齿的假体已经表明，这些材料 表现出优异的机械性能，并可形成化学键， 聚合物基单板材料。FRC种植体假体的两种不同设计 最近开发了：1）螺钉固位，可回收假体和2） 固定的、不可回收的假体。对这两个有重要的需求 设计进行测试，以确定是否有临床上的上级。的 K23奖的候选人建议进行学科内比较 这两种类型的FRC部分种植体假体之间的差异。主 这些假体设计之间的比较将是结局的发生率 需要干预（假体失效或非失效，需要 干预）观察了三年的回忆检查。

DESCRIPTION: (provided by applicant) This application for a K23 award is based upon this candidate's tong-term goal to design and conduct clinical research and develop new dental biomaterials for clinical use. The candidate is board qualified in two clinical dental specialties, Prosthodontics and Periodontics. As a resident and faculty member, he has had opportunities to work with knowledgeable researchers who have guided his efforts in patient-based research. The candidate has developed a good understanding of scientific method and a solid foundation of skills, but seeks to further his research skills to gain independence and more effectively collaborate with biomaterials researchers and biostatisticians. A mentored training program which includes specific areas of didactic training in areas such as clinical research methodology, data management, biostatistics and polymer composite science will allow the candidate to accomplish these goals. The focus of this candidate's research in recent years has been fiber-reinforced composite (FRC) research. The candidate has been involved in developing FRC materials, devising techniques for their use in making dental prostheses and testing these materials and techniques in the laboratory and the clinic. This proposal is designed to provide a clinics test for FRC prostheses used for implant dentistry. Glass FRC materials have been developed which have the potential to make an esthetic dental implant prosthesis substructure without the potential for corrosion and toxicity which may be seen with commonly used metal alloys. Laboratory and clinical research evaluating FRC prostheses used to restore and replace teeth has shown that these materials exhibit excellent mechanical properties and can form a chemical bond to polymer-based veneer materials. Two different designs of FRC implant prostheses have recently been developed: 1) Screw-retained, retrievable prostheses and 2) Luted, non-retrievable prostheses. There is an important need for these two designs to be tested to determine if either is clinically superior. The candidate for this K23 award proposes to make an intra subject comparison between these two types of FRC partial implant prosthesis. The primary comparison between these prosthesis designs will be the incidence of Outcomes Requiring Intervention (failure of prosthesis or non-failures requiring intervention) observed over three years of recall examination.