Evaluation of Fiber Biomaterials for Oral Implantology

用于口腔种植的纤维生物材料的评估

• 批准号: 6752392
• 负责人: MARTIN A FREILICH
• 金额: $ 12.31万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6752392
• 关键词: biomaterial development /preparation; biomaterial evaluation; clinical trials; composite resins; dental implants; dental materials; dental prosthesis; dental radiography; human subject; human therapy evaluation; medical implant science; oral facial restoration; oral facial restoration material; outcomes research; patient oriented research; polymers; statistics /biometry

DESCRIPTION: (provided by applicant) This application for a K23 award is based upon this candidate's tong-term goal to design and conduct clinical research and develop new dental biomaterials for clinical use. The candidate is board qualified in two clinical dental specialties, Prosthodontics and Periodontics. As a resident and faculty member, he has had opportunities to work with knowledgeable researchers who have guided his efforts in patient-based research. The candidate has developed a good understanding of scientific method and a solid foundation of skills, but seeks to further his research skills to gain independence and more effectively collaborate with biomaterials researchers and biostatisticians. A mentored training program which includes specific areas of didactic training in areas such as clinical research methodology, data management, biostatistics and polymer composite science will allow the candidate to accomplish these goals. The focus of this candidate's research in recent years has been fiber-reinforced composite (FRC) research. The candidate has been involved in developing FRC materials, devising techniques for their use in making dental prostheses and testing these materials and techniques in the laboratory and the clinic. This proposal is designed to provide a clinics test for FRC prostheses used for implant dentistry. Glass FRC materials have been developed which have the potential to make an esthetic dental implant prosthesis substructure without the potential for corrosion and toxicity which may be seen with commonly used metal alloys. Laboratory and clinical research evaluating FRC prostheses used to restore and replace teeth has shown that these materials exhibit excellent mechanical properties and can form a chemical bond to polymer-based veneer materials. Two different designs of FRC implant prostheses have recently been developed: 1) Screw-retained, retrievable prostheses and 2) Luted, non-retrievable prostheses. There is an important need for these two designs to be tested to determine if either is clinically superior. The candidate for this K23 award proposes to make an intra subject comparison between these two types of FRC partial implant prosthesis. The primary comparison between these prosthesis designs will be the incidence of Outcomes Requiring Intervention (failure of prosthesis or non-failures requiring intervention) observed over three years of recall examination.

描述：(申请人提供)本K23奖项的申请是基于该候选人设计和进行临床研究的长期目标 并开发临床使用的新型牙科生物材料。候选人是董事会成员 拥有两个临床牙科专业的资格，修复学和牙周学。 作为一名住院医生和教职员工，他有机会与 知识渊博的研究人员指导了他在以患者为基础的研究中的努力 研究。候选人对科学方法有了很好的理解 和扎实的技能基础，但寻求进一步提高他的研究技能 获得独立性，并与生物材料更有效地合作 研究人员和生物统计学家。有指导的培训计划，其中包括 临床研究等领域的教学培训的具体领域 方法论、数据管理、生物统计学和聚合物复合材料科学将 让应聘者实现这些目标。 这位候选人近年来的研究重点是 纤维增强复合材料(FRC)研究这位候选人已经卷入了 开发FRC材料，设计它们在牙科制造中的使用技术 在实验室和实验室对这些材料和技术进行假体和测试 诊所。该提案旨在为frc假体提供临床测试。 用于种植牙科。玻璃FRC材料已经开发出来，已经 制作美观的种植体修复体基础结构的潜力 没有潜在的腐蚀和毒性，可能会看到 常用的金属合金。实验室和临床研究评估FRC 用于修复和替换牙齿的假体表明，这些材料 表现出优异的机械性能，并能与 基于聚合物的贴面材料。两种不同设计的FRC种植义齿 最近开发的有：1)螺丝钉固定的可回收假体和2) 带耳环的、不可回收的假体。对于这两个人来说，有一个重要的需要 需要进行测试的设计，以确定其中一种是否在临床上更好。这个 这项K23奖项的候选人建议进行受试者内比较 在这两种类型的FRC部分种植假体之间。初级阶段 这些假体设计之间的比较将是结果的发生率 需要干预(假体失败或非失败需要 干预)，观察了三年多的召回检查。