IMPACT OF WEIGHT LOSS & EXERCISE ON KNEE OSTEOARTHRITIS

描述（摘自申请人摘要）：Susan Bartlett博士 减肥和运动的临床背景。她致力于临床 据说，她多年来对该公司的投资证明了她的研究。 宾夕法尼亚大学的肥胖研究小组， 学校获得博士学位。研究方法和干预措施方面的培训， 临床心理学家，以及完成了一个奖学金的重量 约翰霍普金斯医学院的管理。膝关节骨关节炎（OA）是 这是一个影响美国数百万人的重大公共卫生挑战。肥胖 是干预的主要目标，因为它占膝关节的30% OA会加重症状，并与双侧受累相关， 疾病的快速发展。而美国修辞学院 实践指南建议适度减肥作为对症治疗， 迄今为止，还没有发表的临床试验研究减肥的影响。 膝关节OA体力活动也与疼痛减轻有关， 膝关节OA患者的活动性增加，应纳入治疗 (ACR实践指南）。运动可能对超重特别有帮助 因为它是维持体重减轻的有效预测因子。 虽然坚持传统的锻炼计划一直很差， 一天中积累的锻炼似乎是一个有希望的新方法， 接近身体活动。生活方式的体力活动 对健康和减肥都有好处。生活方式锻炼也可以提高 通过增加活动选项和减少时间来锻炼依从性 隔栏.间歇性的体力活动可能比持续性的体力活动更可取。 运动可以减轻疼痛，避免受伤。 本提案的主要目的是评估减肥的影响 和生活方式锻炼对膝关节骨性关节炎的影响。为了实现这一目标，156 有症状的膝关节OA超重患者将随机接受 16-每周计划：1）减肥+生活方式体育活动;或2） 健康教育（对照）。主要结局指标为膝关节疼痛。 次要指标包括身体残疾、生活质量、表现 措施和长期坚持行为改变。本研究将提供 将行为改变纳入膝关节OA治疗的数据。

DESCRIPTION (Taken from the applicant's abstract): Dr. Susan Bartlett has a clinical background in weight loss and exercise. Her commitment to clinical research is said to be demonstrated by her investment of many years with the Obesity Research Group at the University of Pennsylvania, return to graduate school obtain Ph.D. training in research methodology and interventions as a clinical psychologist, as well as completion of a fellowship in Weight Management at the Johns Hopkins School of Medicine. Knee osteoarthritis (OA) is a major public health challenge affecting millions of people in the US. Obesity is a primary target for intervention since it accounts for up to 30% of knee OA, exacerbates symptoms and is associated with bi-lateral involvement and more rapid progression of the disease. While the American College of Rheumatology Practice Guidelines recommends modest weight loss as symptomatic therapy, to date no published clinical trials have investigated the impact of weight loss on knee OA. Physical activity has also been associated with pain reduction and increased mobility in individuals with knee OA and should included in treatment (ACR Practice Guidelines). Exercise may be especially helpful for overweight persons with knee OA as it is a potent predictor of maintenance of weight loss. Though adherence to traditional exercise programs has been poor, lifestyle in which exercise is accumulated throughout the day appears to be a promising new approach to physical activity. Lifestyle physical activity has been associated with both health and weight loss benefits. Lifestyle exercise may also enhance exercise adherence by increasing options to be active and reducing time barriers. Episodes of physical activity may be preferable to continuous exercise in reducing pain and avoiding injury. The primary objective of this proposal is to evaluate the impact of weight loss and lifestyle exercise on knee osteoarthritis. To accomplish this, 156 overweight persons with symptomatic knee OA will be randomized to receive a 16-week program of: 1 ) a weight loss + lifestyle physical activity; or 2) health education (control). The primary outcome measure will be knee pain. Secondary measures include physical disability, quality of life, performance measures and long-term adherence to behavior change. This study will provide data on integrating behavioral changes into the treatment of knee OA.