IMPACT OF WEIGHT LOSS ON KNEE OSTEOARTHRITIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。膝关节骨关节炎（OA）是影响美国数百万人的主要公共卫生挑战。高达30%的膝关节OA可归因于肥胖，肥胖会加重症状，与双侧问题相关，并加速疾病的进展。关于体重减轻对膝关节骨性关节炎严重程度和进展的有效性的已发表临床试验很少。本方案的目的是评价体重减轻加生活方式体力活动对膝关节OA症状和功能的疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Knee Osteoarthritis (OA) is a major public health challenge affecting millions of people in the U.S. Up to 30% of knee OA can be attributed to obesity, which exacerbates symptoms, is associated with bilateral problems and accelerates progression of the disease. There have been few published clinical trials on the efficacy of weight loss of the severity and progression of knee OA. The purpose of this protocol is to evaluate the efficacy of weight loss plus lifestyle physical activity on knee OA symptoms and functioning.