Study of Osteoporotic Fractures

描述(申请人提供)：骨质疏松性骨折研究(SOF) 是一项多中心纵向研究，对9704名老年女性进行了队列研究。索夫哈斯 关于骨质疏松症和其他疾病的风险因素的综合数据， 以及一份血清、棕黄色大衣和尿液样本的档案。来自SOF的数据 用于：(1)制定骨质疏松症指南，(2)估计 骨质疏松症筛查的成本效益，以及(3)规划试验 骨质疏松症疗法。他们建议更新SOF以保持这一独特的 资源，并提出几个新的假设。骨质疏松症是一种慢性疾病 疾病和骨折的预防必须从非常长远的角度考虑， 不仅仅是该领域大多数研究的3-5年持续时间。作为研究的对象 随着骨质疏松症和老龄化的最长(近15年)的随访，SOF将 为描述识别最高风险人群的方法提供基础 骨质疏松症和骨折的可能性提前了几十年。他们设想了一个新的 基于长期风险预测的临床指南的生成 骨折和残疾。因为他们让队列变得更加丰富 非裔美国妇女，SOF还将提供关于风险的独特信息 老年非裔美国人骨质疏松和非脊柱骨折的相关因素 女人。Sof是第一个显示低骨密度与高血压风险之间联系的研究。 中风，这有助于激发人们的兴趣和对 动脉钙化与骨质疏松之间的联系。如果他们示威， 并可以开始解释，这两种疾病之间的联系，这可能会导致 同时降低两种疾病风险的筛查工具和治疗 这些禁用条件。SOF的初步结果表明，受损的 睡眠可能是老年人骨折、残疾和认知能力下降的主要原因 年长的女人。如果SOF的下一阶段使用更多 客观测量失眠和其他睡眠障碍，那么这可能 改变当前的临床政策和做法，进行更积极的筛查 以及更好地覆盖睡眠障碍的治疗。最后，SOF的价值 可以通过招募其他科学家来研究SOF数据和 样本。他们建议让调查人员很容易地访问数据库 并帮助他们有效地利用数据库，该数据库 代表着最全面的潜在信息来源之一 关于老年女性的健康。

DESCRIPTION (provided by applicant): The Study of Osteoporotic Fractures (SOF) is a multi-center longitudinal study in a cohort of 9,704 older women. SOF has comprehensive data about risk factors for osteoporosis and other diseases, along with an archive of serum, buffy coat and urine specimens. Data from SOF have served for: (1) developing osteoporosis guidelines, (2) estimating the cost-effectiveness of screening for osteoporosis, and (3) planning trials of osteoporosis therapies. They propose to renew SOF to sustain this unique resource and to pursue several new hypotheses. Osteoporosis is a chronic disease and prevention of fractures must be considered over the very long-term, not just the 3-5 year duration of most studies in the field. As the study of osteoporosis and aging with the longest (nearly 15 years) follow-up, SOF will provide the foundation for describing ways to identify people at greatest risk of osteoporosis and fractures decades in advance. They envision a new generation of clinical guidelines based on long-term prediction of risk of fractures and disability. Because they have enriched the cohort with African-American women, SOF will also provide unique information on risk factors for osteoporosis and non-spine fractures in older African American women. SOF was the first study to show a link between low BMD and risk of stroke and this has helped to fuel the interest and new investigations about the links between arterial calcification and osteoporosis. If they demonstrate, and can begin to explain, the link between these two diseases, this may lead to screening tools and treatments that simultaneously decrease the risk of both of these disabling conditions. Preliminary results from SOF suggest that impaired sleep may be a major cause of fractures, disability and decline in cognition in older women. If the next phase of SOF confirms these relationships using more objective measures of insomnia and other sleep disorders, then this might change current clinical policies and practices toward more aggressive screening and better coverage for treatment of sleep disorders. Finally, the value of SOF could be magnified by recruiting other scientists to work on SOF data and samples. They propose to make the database easily accessible to investigators outside of SOF and assist them in making productive use of a database that represents one of the most comprehensive prospective sources of information about the health of older women.