Study of Osteoporotic Fractures (SOF)

描述(申请人提供)：骨质疏松性骨折(SOF)研究是一组10,366名妇女的队列，她们在1986-2007年登记时年龄大于或等于65岁。在18年和8次检查中，SOF开发了一系列全面的表型数据，以及53,000个生物标本和67,500张X光照片的档案。SOF的研究结果发表在235篇论文中，形成了预防骨折的临床实践和指南，并促进了对认知功能、乳腺癌、骨关节炎和其他与年龄相关的疾病的理解。SOF继续卓有成效，自2000年我们上次续订以来，已发表了93篇文章，其中包括来自45名外部调查人员的60篇文章，其中大部分是初级调查人员。所有SOF数据现在都可以通过SOF Online公开获得。我们计划从这些独特的SOF资源中维持、建立和产生重要的发现。特种部队已经成为9岁和10岁女性中规模最大、时间最长、特征最好的群体之一，这是美国人口中增长最快的部分。除了关于危险因素、骨量和骨折的数据外，我们还有近20年的关于下肢功能、认知功能和跌倒的系列评估。在20年的考试中，我们将在临床或家庭中检查幸存的SOF参与者，以新的维度扩展我们的认知功能评估，并使用标准化和验证的短体能成套测验评估下肢功能。这些检查将使我们能够分析为什么一些女性在晚年拥有出色的认知功能和腿部功能。我们将使用我们第10年考试中储存的血液来检验这样的假设：优秀的肾功能、低水平的炎症和正常的25(OH)维生素D水平与维持和实现卓越的下肢功能、高认知功能、低跌倒风险和低髋部骨折风险在第9和第10年的生命中相关。潜在的公共健康影响：虽然年龄最大的老年妇女是美国人口中增长最快的部分，但人们对如何保持她们的独立性知之甚少。肾功能、炎症和维生素D水平是可以改变的。如果我们的假设诞生了，这可能会导致关于生活方式、维生素D补充剂或药物的试验和建议，以促进晚年的高水平功能。

DESCRIPTION (provided by applicant): The Study of Osteoporotic Fractures (SOF) is a cohort of 10,366 women who were greater than or equal to 65 years old at enrollment in 1986-7. During 18 years and 8 examinations, SOF has developed a comprehensive array of phenotypic data, along with archives of 53,000 biological specimens and 67,500 radiographs. Findings from SOF, reported in 235 papers, have shaped clinical practice and guidelines for fracture prevention, and advanced the understanding of cognitive function, breast cancer, osteoarthritis, and other age-related conditions. SOF continues to be very productive, with 93 publications since our last renewal in 2000, including 60 articles from 45 external, and mostly junior, investigators. All SOF data are now available publicly via SOF Online. We propose to sustain, build, and produce important discoveries from these unique SOF resources. The SOF cohort has become one of the largest, longest, and best characterized cohorts of women in the 9th and 10th decades of life, the fastest growing segment of the US population. In addition to data about risk factors, bone mass, and fractures, we have nearly two decades of serial assessments of lower extremity function, cognitive function, and falls. In a Year 20 Exam, we will examine surviving SOF participants in clinic or home to expand our assessment of cognitive function with new dimensions and assess lower extremity function using the standardized and validated Short Physical Performance Battery. These examinations will allow us to analyze why some women have excellent cognitive function and lower extremity function so late in life. We will use blood stored from our Year 10 Exam to test the hypotheses that excellent renal function, low levels of inflammation, and normal levels of 25(OH)Vitamin D are associated with maintaining and achieving excellent lower extremity function, high cognitive function, a low risk of falls, and a low risk of hip fracture into the 9th and 10th decades of life. Potential public health impacts: While the oldest old women are the fastest growing segment of the US population, little is known about how to maintain their independence. Renal function, inflammation, and vitamin D levels are modifiable. If our hypotheses are born out, this may lead to trials and recommendations about lifestyle, vitamin D supplementation, or medication, to promote high levels of function late in life.