4 of 4: Study of Osteoporotic Fractures (SOF) - Portland Clinical Center

描述（由申请人提供）：本提案要求在我们竞争性更新和（部分）资助的5年研究的第4年和第5年期间，支持临床中心研究人员在骨质疏松性骨折（SOF）研究中分析数据、发表结果并继续参与SOF的科学研究。我们没有要求支持收集数据或分析样本，我们没有改变资助的5年研究的任何方面。2006年8月对SOF进行了更新，以研究为什么一些妇女在生命的第9和第10个十年中获得了良好的下肢和认知功能，以及为什么一些妇女在10年的随访中保持了健康的下肢和认知功能轨迹。我们正在专门测试肾功能、炎症和维生素D对维持和实现高水平的功能以及降低跌倒和髋部骨折的风险是否重要。每个SOF临床中心PI都带头制定一个SOF目标。美国国立卫生研究院资助了我们的20年级考试，我们在考试中测量认知和下肢功能。我们的目标是在2008年9月底之前完成访问，这样我们就可以开始选择和提取样本，并在第三年晚些时候开始进行生物标记分析。大部分数据将在续期的第4年和第5年进行分析并撰写论文。临床中心的研究人员——包括年轻的研究人员——将承担大部分的工作。协调中心的资助为期5年。然而，临床中心只获得了3年的资助（8/1/06-7/31/09）来完成考试。临床中心3年的资金限制无意间会阻止临床中心的研究人员分析和发表他们制定的目标的结果。因此，我们要求支持SOF临床中心的研究人员在我们续期的第4年和第5年分析和发表这项资助的竞争性续期的结果，并继续他们对SOF科学活动的必要参与。此外，NIA要求我们在本提案中包括一个关于SOF的公共数据共享的计划。我们的计划建立在我们成功的公共访问门户网站SOF Online上，并建议在网站上添加可下载和记录的公共发布数据集，以允许外部调查人员直接访问已确定的SOF数据。公共卫生相关性：骨质疏松性骨折（SOF）的研究竞争性更新，以研究为什么一些女性在生命的第9和第10个十年达到并保持高认知和身体功能，以及低跌倒和骨折的风险。SOF协调中心的资助期限为5年；在软体外科临床中心工作3年。为了实现这些目标，我们要求为SOF临床中心提供两年的支持。

DESCRIPTION (provided by applicant): This proposal requests support for the investigators in the Clinical Centers in the Study of Osteoporotic Fractures (SOF) to analyze data, publish results, and continue scientific participation in SOF during the 4th and 5th years of our competitively renewed and (partially) funded 5 year study. We are NOT requesting support for collecting data or assaying samples and we have NOT changed any aspect of the funded 5 year study. SOF was renewed in August 2006 to study why some women achieve excellent lower extremity and cognitive function in the 9th and 10th decades of life and why some women have maintained healthy trajectories of lower extremity and cognitive function over 10 years of follow-up. We are specifically testing whether renal function, inflammation, and vitamin D are important to maintaining and achieving high levels of function and lower risks of falls, and hip fractures. Each SOF Clinical Center PI took the lead in developing one of the SOF Aims. NIH funded our Year 20 Exam in which we are measuring cognitive and lower extremity function. We are on target to complete the visits by the end of September, 2008 so that we can begin to select and pull samples and start biomarker assays later in that 3rd year. The bulk of the data will be analyzed and papers produced in the 4th and 5th years of the renewal. Investigators at the Clinical Centers - including young investigators - would do most of that work. The Coordinating Center was funded for 5 years. However, Clinical Centers were funded for only 3 years (8/1/06-7/31/09) just to complete the Exam. The 3 year limit on Clinical Center funding would - inadvertently - prevent the Clinical Center investigators from analyzing and publishing results from the aims they developed. Therefore, we request support for the SOF Clinical Center investigators to analyze and publish results from this funded competitive renewal during the 4th and 5th years of our renewal and continue their essential participation in the scientific activities of SOF. In addition, NIA requested that we include a plan for public data sharing for SOF in this proposal. Our plan builds on our successful public access web portal, SOF Online, and proposes to add downloadable and documented public release data sets to the website to allow external investigators direct access to identified SOF data. PUBLIC HEALTH RELEVANCE: The Study of Osteoporotic Fractures (SOF) was competitively renewed to study why some women achieve and maintain high cognitive and physical function, and low risk of falls and fractures in the 9th and 10th decade of life. The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers.