DC AIDS MALIGNANCY BANK

描述：（申请人的描述） 艾滋病基金会成立于1994年，自1995年以来， 由五个地点组成：加州大学旧金山分校，加州大学洛杉矶分校，乔治华盛顿大学， 纽约州立大学布鲁克林分校和俄亥俄州州立大学。 AMB是国家资源 这反映了样本中艾滋病的恶性肿瘤的历史。 因为AMB的科学家们自己也积极参与了 在艾滋病相关恶性肿瘤的发生过程中，AMB对 艾滋病毒疾病的治疗和科学进展。 目前，AMB 包含43个不同类别的12，688个个体标本。 这些 液体、细胞和组织标本，沿着相关临床 信息，提供给世界各地合格的研究人员。 迄今为止， 不同的研究人员收到了900多个标本， 由独立研究机构对其意向书（LOI）进行评估， 评价决定小组（REDP）的专家在该领域。 目前的再竞争提案结合了所有AMB成员的信息 网站，以及报告成绩，未来的计划，目标和预算 个别网站的预测。 AMB的主要目标是：1）建立 一个运营中心，将维护国家数据库，协调 AMB站点的活动，并与外部资源接口， 例如艾滋病相关的艾滋病联盟和妇女组织， 机构间艾滋病毒研究和科学界; 2）扩大AMB， 作为大型肿瘤临床的标本库， 流行病学财团，最终导致采购他们的 标本，3）增加知名度和扩大使用的电磁轴承， 调查员，以及4）进一步开发个人会员网站计划 以增加样本采集。 哥伦比亚特区艾滋病储备银行（D.C.AMB）的目标仍然是： 发展和维护一个全面的、用户友好的组织库， 来自表现出HIV相关性的个体的B i体液标本 恶性肿瘤和对照样本。 特区安博会有存款31865美元 来自已知HIV阳性个体的1885例病例的个体标本， 艾滋病病毒感染状况不明的人。 D.C.AMB一直是一个 国家AMB指导委员会的积极参与者，已经发布了 研究人员的标本，并产生了AMB标本处理手册。 华盛顿AMB财团的新成员，约翰霍普金斯 大学、武装部队病理学研究所和凯撒医疗机构， 与乔治华盛顿大学的继续成员一起， 乔治城大学、霍华德大学、迈阿密大学及其 巴西的合作者，儿童医院国家医疗中心和 费尔法克斯医院确保扩大地理区域，以提高类型 以及特区电磁轴承中的样本数量

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Bank was established in 1994, and since 1995 has been composed of five sites: UCSF, UCLA, George Washington University, SUNY-Brooklyn, and Ohio State University. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the p a t hogenesis of AIDS-related malignancies, the AMB is responsive to therapeutic and scientific advances in HIV disease. Currently, the AMB contains 12,688 individual specimens in 43 different categories. These fluid, cell, and tissue specimens, along with associated clinical information, are available to qualified researchers worldwide. To date, 18 different investigators have received over 900 specimens after critical evaluation of their Letters of Intent (LOIs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This current recompetition proposal combines information from all AMB member sites, as well as reporting accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish an Operations Center that will maintain the national database, coordinate activities of the AMB sites, and interface with external sources of specimens such as the AIDS-related Malignancy Consortium and the Women's Interagency HIV Study, and the scientific community; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens, 3) to increase visibility and broaden the use of the AMB by investigators, and 4) to f u rther develop individual member site programs to increase specimen acquisition. The goal of the D.C.AIDS Malignancy Bank (D.C.AMB) continues to be the growth and maintenance of a comprehensive, user-friendly bank of tissue and b i o logical fluid specimens from individuals demonstrating HIV-related malignancies and control specimens. The D.C. AMB has on deposit 31,865 individual specimens from 1885 cases from known HIV-positive individuals and from individuals whose HIV-status is unknown. The D.C.AMB has been an active participant of the National AMB Steering Committee, has released specimens to researchers, and produced the AMB Specimen Processing Manual. The new composition of the D.C. AMB Consortium new members, John Hopkins University, the Armed Forced Institute of Pathology, and Kaiser Permanente, together with the continuing members of George Washington University, Georgetown University, Howard University, University of Miami with their collaborators in Brazil, Children's Hospital National Medical Center and Fairfax Hospital ensures an expanded geographical area to enhance the types and numbers of specimens in the D.C. AMB.