DC AIDS MALIGNANCY BANK

描述：(申请人描述) 艾滋病恶性病毒库成立于1994年，自1995年以来一直 由五个站点组成：加州大学旧金山分校、加州大学洛杉矶分校、乔治华盛顿大学、 纽约州立大学布鲁克林分校和俄亥俄州立大学。AMB是国家资源 这反映了样本中艾滋病毒疾病的恶性病史。 因为AMB的科学家们自己都在积极参与研究 艾滋病相关恶性肿瘤的发病机制，AMB对 艾滋病毒疾病的治疗和科学进展。目前，AMB 包含43个不同类别的12,688个个体标本。这些 体液、细胞和组织标本，以及相关的临床 世界各地的合格研究人员都可以获得这些信息。到目前为止，18 不同的调查人员在危急关头收到了900多个样本 通过独立研究和评估他们的意向书(LOIS) 该领域专家的评价决策小组(REDP)。 当前的重新竞争提案结合了来自AMB所有成员的信息 网站，以及报告成绩、未来计划、目标和预算 来自各个站点的预测。AMB的主要目标是：1)建立 一个运营中心，将维护国家数据库，协调 AMB站点的活动，以及与外部来源的接口 标本，如艾滋病相关恶性肿瘤协会和妇女 机构间艾滋病毒研究和科学界；2)将AMB扩大到 作为大型肿瘤学临床和临床的标本库 流行病学财团，最终导致采购其 标本，3)通过以下方式提高AMB的可见性和扩大其用途 调查人员，以及4)进一步开发个人成员站点程序 增加标本采集量。 D.C.AIDS恶性银行(D.C.AMB)的目标仍然是 生长和维护一个全面的、用户友好的组织库和 来自HIV相关患者的逻辑体液样本 恶性肿瘤和对照标本。D.C.Amb有31,865英镑的存款 1885例已知艾滋病毒阳性者的个人样本和 来自艾滋病毒状况不明的个人。华盛顿特区AMB一直是一个 国家AMB指导委员会的积极参与者，发布了 标本交给研究人员，并制作了《AMB标本处理手册》。 D.C.AMB联盟的新成员约翰·霍普金斯 大学、武装部队病理研究所和Kaiser Permanente， 与乔治·华盛顿大学的留任成员一起， 乔治敦大学、霍华德大学、迈阿密大学 在巴西的合作者、儿童医院国家医疗中心和 费尔法克斯医院确保扩大地理区域以增强类型 以及华盛顿特区AMB的标本数量。

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Bank was established in 1994, and since 1995 has been composed of five sites: UCSF, UCLA, George Washington University, SUNY-Brooklyn, and Ohio State University. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the p a t hogenesis of AIDS-related malignancies, the AMB is responsive to therapeutic and scientific advances in HIV disease. Currently, the AMB contains 12,688 individual specimens in 43 different categories. These fluid, cell, and tissue specimens, along with associated clinical information, are available to qualified researchers worldwide. To date, 18 different investigators have received over 900 specimens after critical evaluation of their Letters of Intent (LOIs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This current recompetition proposal combines information from all AMB member sites, as well as reporting accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish an Operations Center that will maintain the national database, coordinate activities of the AMB sites, and interface with external sources of specimens such as the AIDS-related Malignancy Consortium and the Women's Interagency HIV Study, and the scientific community; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens, 3) to increase visibility and broaden the use of the AMB by investigators, and 4) to f u rther develop individual member site programs to increase specimen acquisition. The goal of the D.C.AIDS Malignancy Bank (D.C.AMB) continues to be the growth and maintenance of a comprehensive, user-friendly bank of tissue and b i o logical fluid specimens from individuals demonstrating HIV-related malignancies and control specimens. The D.C. AMB has on deposit 31,865 individual specimens from 1885 cases from known HIV-positive individuals and from individuals whose HIV-status is unknown. The D.C.AMB has been an active participant of the National AMB Steering Committee, has released specimens to researchers, and produced the AMB Specimen Processing Manual. The new composition of the D.C. AMB Consortium new members, John Hopkins University, the Armed Forced Institute of Pathology, and Kaiser Permanente, together with the continuing members of George Washington University, Georgetown University, Howard University, University of Miami with their collaborators in Brazil, Children's Hospital National Medical Center and Fairfax Hospital ensures an expanded geographical area to enhance the types and numbers of specimens in the D.C. AMB.