CORE--PHENOTYPIC ANALYSIS

核心--表型分析

• 批准号: 6478160
• 负责人: Makio Ogawa
• 金额: $ 7.67万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478160
• 关键词: animal tissue; biomedical facility; cytology; gene targeting; genetic manipulation; genetically modified animals; histology; laboratory mouse; mutant; phenotype; tissue resource /registry

This core is developed to meet the need for morphological, histological and cytological screening of new mouse mutants produced by Core B for all Projects of this proposal. Because a number of such genetically manipulated mice will be created and because those generating the mice are in most cases not trained in all aspects of mouse physiology and histology, a core facility is necessary to insure that all phenotypes are accurately identified. Quality control procedures will be implemented to ensure reliability and consistency in the analyses. The core will be supervised by Dr. Makio Ogawa, who is a board certified hematologist and experienced in the development of mouse hematopoietic systems. In addition. Dr. Sarah Bingel (Veterinary Pathologist) of MUSC, will be in charge of analyzing the tissue and organ samples.

该核心是为了满足形态学、组织学 和细胞学筛选由核心B产生的新小鼠突变体， 本提案的项目。因为许多这样的基因 操纵小鼠将被创造出来，因为那些产生小鼠的人是 在大多数情况下，没有接受过小鼠生理学所有方面的训练， 组织学，一个核心设施是必要的，以确保所有表型， 准确识别。将实施质量控制程序， 确保分析的可靠性和一致性。芯会 由Makio Ogawa博士监督，他是一名委员会认证的血液学家， 在小鼠造血系统的发展方面经验丰富。在 的增订条文MUSC的Sarah Bingel博士（兽医病理学家）将在 负责分析组织和器官样本。