ERP Measures of Auditory Perceptual Processing

描述(由申请者提供)：建议的拨款将提供职业 发展和培训以及对研究的支持。总体目标是 将科研培训与我的临床经验相结合，使这两种经历 更有效、更有意义。职业发展将包括正式的 听觉事件相关电位基础基础科学的课程作业 (ERPS)，包括神经科学、神经解剖学和生理学。指导职业生涯 发展将包括多渠道应急方案领域，包括地形 分析、大脑开发、ERP成熟和负责任的行为 研究。进一步的活动将包括前往受人尊敬的实验室 电生理学，以及出席国内和国际临床和 科学会议。(不包括多元统计的课程作业， 因为我有三个博士级别的课程)。 声学改变复合体(ACC)是皮层产生的ERP SEW 在持续声音的声学变化后大约100毫秒。建议数 研究将确定ACC是否可以用作有效的临床 听觉知觉加工的电生理测试。主要问题 要解决的问题包括：1)ACC是否是可靠和稳定的检查工具 声音变化的处理？2)最有效的方法是什么 引发ACC，以最大限度地减少患者测试时间和最大化Access 波幅？3)在儿童中可靠地诱发ACC吗？如果是这样，它是如何 随着成熟而变化？4)ACC能用来预测行为吗？ 听力损失听者的辨别表现？5)这些角色是什么 在ACC生成中初级和次级皮质区的比例？

DESCRIPTION (provided by applicant): The proposed grant will provide for career development and training as well as support for research. The overall goal is to combine research training with my clinical experience to make both experiences more effective and more meaningful. Career development will include formal course work in the basic science underlying auditory event-related potentials (ERPs), including neuroscience, and neuroanatomy & physiology. Mentored career development will include the areas of multi-channel ERPs, including topographic analysis, brain development, ERP maturation, and the responsible conduct of research. Further activities will include travel to respected laboratories in electrophysiology, and attendance at national and international clinical and scientific conferences. (Course work in multivar1ate statistics is not included, as I have had three courses at the doctoral level). The acoustic change complex (ACC) is a cortically generated ERP seen approximately 100 ms after an acoustic change in an ongoing sound. The proposed research will determine whether the ACC can be used as an efficient clinical electrophysiological test of auditory perceptual processing. The major questions to be addressed include: 1) Is the ACC a reliable and stable tool for examining the processing of acoustic change? 2) What is the most efficient means of eliciting the ACC in order to minimize patient testing time and maximize ACC amplitude? 3) Is the ACC reliably elicited in children? If so, how does it change with maturation? 4) Can the ACC be used to predict behavioral discrimination performance in listeners with hearing loss? 5) What are the roles of primary and secondary cortical fields in ACC generation?