ERP Measures of Auditory Perceptual Processing

听觉感知处理的 ERP 测量

• 批准号: 7252928
• 负责人: BRETT A MARTIN
• 金额: $ 12.95万
• 依托单位: CUNY GRADUATE SCH AND UNIV CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7252928
• 关键词: acoustic nerve; adult human (21+); aging; auditory cortex; auditory discrimination; auditory stimulus; auditory threshold; behavioral /social science research tag; child (0-11); clinical research; cognition; electrodes; electrophysiology; evoked potentials; hearing disorders; human subject; language; neural information processing; neuropsychological tests; performance; sound perception; speech; stimulus interval

DESCRIPTION (provided by applicant): The proposed grant will provide for career development and training as well as support for research. The overall goal is to combine research training with my clinical experience to make both experiences more effective and more meaningful. Career development will include formal course work in the basic science underlying auditory event-related potentials (ERPs), including neuroscience, and neuroanatomy & physiology. Mentored career development will include the areas of multi-channel ERPs, including topographic analysis, brain development, ERP maturation, and the responsible conduct of research. Further activities will include travel to respected laboratories in electrophysiology, and attendance at national and international clinical and scientific conferences. (Course work in multivar1ate statistics is not included, as I have had three courses at the doctoral level). The acoustic change complex (ACC) is a cortically generated ERP seen approximately 100 ms after an acoustic change in an ongoing sound. The proposed research will determine whether the ACC can be used as an efficient clinical electrophysiological test of auditory perceptual processing. The major questions to be addressed include: 1) Is the ACC a reliable and stable tool for examining the processing of acoustic change? 2) What is the most efficient means of eliciting the ACC in order to minimize patient testing time and maximize ACC amplitude? 3) Is the ACC reliably elicited in children? If so, how does it change with maturation? 4) Can the ACC be used to predict behavioral discrimination performance in listeners with hearing loss? 5) What are the roles of primary and secondary cortical fields in ACC generation?

描述（由申请人提供）：拟议的赠款将提供职业生涯 发展和培训以及对研究的支持。总体目标是 将联合收割机研究培训与我的临床经验结合起来， 更有效更有意义职业发展将包括正式的 听觉事件相关电位基础科学课程 （ERP），包括神经科学，神经解剖学和生理学。导师职业 发展将包括多渠道ERP领域，包括地形 分析，大脑发育，ERP成熟，以及负责任的行为 research.进一步的活动将包括前往受尊重的实验室， 电生理学，并出席国家和国际临床和 科学会议。（多元统计课程不包括在内， 因为我有三门博士课程）。 声学变化复合体（ACC）是一种皮层产生的ERP， 在进行中的声音的声学变化之后大约100 ms。拟议 研究将确定ACC是否可以用作有效的临床 听觉知觉处理的电生理学测试。的主要问题 需要解决的问题包括：1）ACC是否是一个可靠和稳定的工具， 声音变化的过程2)最有效的方法是什么 引发ACC，以便最大限度地减少患者测试时间并最大限度地提高ACC 振幅？3)儿童的ACC是否可靠？如果是这样， 随着成熟而变化？4)ACC是否可用于预测行为 听力损失患者的辨别能力5)有哪些角色 初级和次级皮质区在ACC产生中的作用

项目成果

Stimulus presentation strategies for eliciting the acoustic change complex: increasing efficiency.

• DOI: 10.1097/aud.0b013e3181ce6355
• 发表时间: 2010-06
• 期刊: Ear and hearing
• 影响因子: 3.7
• 作者: Martin BA;Boothroyd A;Ali D;Leach-Berth T
• 通讯作者: Leach-Berth T