ERP Measures of Auditory Perceptual Processing

听觉感知处理的 ERP 测量

• 批准号: 6741467
• 负责人: BRETT A MARTIN
• 金额: $ 15.81万
• 依托单位: SETON HALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741467
• 关键词: acoustic nerve; adult human (21+); aging; auditory cortex; auditory discrimination; auditory stimulus; auditory threshold; behavioral /social science research tag; child (0-11); clinical research; cognition; electrodes; electrophysiology; evoked potentials; hearing disorders; human subject; language; neural information processing; neuropsychological tests; performance; sound perception; speech; stimulus interval

DESCRIPTION (provided by applicant): The proposed grant will provide for career development and training as well as support for research. The overall goal is to combine research training with my clinical experience to make both experiences more effective and more meaningful. Career development will include formal course work in the basic science underlying auditory event-related potentials (ERPs), including neuroscience, and neuroanatomy & physiology. Mentored career development will include the areas of multi-channel ERPs, including topographic analysis, brain development, ERP maturation, and the responsible conduct of research. Further activities will include travel to respected laboratories in electrophysiology, and attendance at national and international clinical and scientific conferences. (Course work in multivar1ate statistics is not included, as I have had three courses at the doctoral level). The acoustic change complex (ACC) is a cortically generated ERP seen approximately 100 ms after an acoustic change in an ongoing sound. The proposed research will determine whether the ACC can be used as an efficient clinical electrophysiological test of auditory perceptual processing. The major questions to be addressed include: 1) Is the ACC a reliable and stable tool for examining the processing of acoustic change? 2) What is the most efficient means of eliciting the ACC in order to minimize patient testing time and maximize ACC amplitude? 3) Is the ACC reliably elicited in children? If so, how does it change with maturation? 4) Can the ACC be used to predict behavioral discrimination performance in listeners with hearing loss? 5) What are the roles of primary and secondary cortical fields in ACC generation?

描述（由申请人提供）：拟议的补助金将提供职业生涯 开发和培训以及研究支持。总体目标是 将研究培训与我的临床经验相结合，使这两种经历 更有效、更有意义。职业发展将包括正式的 听觉事件相关电位的基础科学课程作业 （ERP），包括神经科学、神经解剖学和生理学。指导职业 开发将包括多渠道 ERP 领域，包括地形 分析、大脑发育、ERP 成熟以及负责任的行为 研究。进一步的活动将包括前往受人尊敬的实验室 电生理学，以及参加国内和国际临床和 科学会议。 （不包括多元统计课程作业， 因为我已经选修了三门博士课程）。 声学变化复合体 (ACC) 是皮质生成的 ERP 持续声音发生声学变化后大约 100 毫秒。拟议的 研究将确定 ACC 是否可以用作有效的临床 听觉感知处理的电生理测试。主要问题 需要解决的问题包括： 1) ACC 是否是一个可靠且稳定的检查工具？ 声学变化的处理？ 2）最有效的方法是什么 引发 ACC，以最大限度地减少患者测试时间并最大化 ACC 振幅？ 3) ACC 在儿童中的引出是否可靠？如果是这样，怎么办 随着成熟而改变？ 4）ACC可以用来预测行为吗 听力损失听众的辨别能力？ 5）有哪些角色 ACC 生成中的初级和次级皮质区？