Magnetic Resonance Guided Therapy of Cardiac Arhythmia ( MaRGiTA)

磁共振引导心律失常治疗 (MaRGiTA)

• 批准号: TS/G002142/1
• 负责人: Tobias Richard Schaeffter
• 金额: $ 62.87万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=TS%2FG002142%2F1
• 关键词: Magnetic; Resonance; Guided; Therapy; Cardiac

This project will develop novel devices and imaging technology for minimal-invasive treatment of cardiac arrhythmias, a major healthcare problem affecting 5.3% of the UK population. Currently diagnosis and treatment of cardiac arrhythmia is performed under X-ray guidance. This imaging modality offers no 3D information and no soft tissue contrast, the procedure takes several hours, resulting in significant radiation exposure to patient and medical staff. This project will develop the first Magnetic Resonance (MR) guided arrhythmia therapy procedure using a novel catheter device. The new procedure will avoid radiation dose completely. Furthermore, non-invasive MR-techniques will also be developed as a biomarker of the arrhythmia treatment. The project will be performed in three phases.Phase 1. Prototyping: In the first phase catheter prototypes and MR-tracking techniques will be developed. In parallel, MR-techniques to image and quantify ablation lesions will be developed and tested with lesions made by standard ablation catheters under X-ray and subsequent evaluation under MR in our X-MR facilities. Phase 2. Preclinical Test: During the second phase catheter prototypes and MR ablation lesion imaging will be optimized and tested in a preclinical model.Phase 3. Clinical Feasibility. During the third phase clinical catheter prototypes will be developed and after obtaining regulatory approval, these will be tested in a limited number of patients.

该项目将开发用于微创治疗心律失常的新型设备和成像技术，心律失常是影响5.3%英国人口的主要医疗保健问题。目前，心律失常的诊断和治疗是在X射线引导下进行的。这种成像模式不提供3D信息，也没有软组织对比度，手术需要几个小时，导致患者和医务人员受到大量辐射。本项目将开发首个使用新型导管器械的磁共振（MR）引导心律失常治疗程序。新程序将完全避免辐射剂量。此外，非侵入性MR技术也将被开发为心律失常治疗的生物标志物。该项目将分三个阶段进行。原型：在第一阶段，将开发导管原型和MR跟踪技术。与此同时，将开发用于消融病变成像和量化的MR技术，并在我们的X-MR设施中使用标准消融导管在X射线下制作的病变进行测试，并随后在MR下进行评价。第二阶段。临床前试验：在第二阶段，导管原型和MR消融病变成像将在临床前模型中进行优化和测试。临床可行性。在第三阶段，将开发临床导管原型，并在获得监管批准后，将在有限数量的患者中进行测试。

项目成果

Prospective high-resolution respiratory-resolved whole-heart MRI for image-guided cardiovascular interventions.

• DOI: 10.1002/mrm.23216
• 发表时间: 2012-07
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Kolbitsch, Christoph;Prieto, Claudia;Buerger, Christian;Harrison, James;Razavi, Reza;Smink, Jouke;Schaeffter, Tobias
• 通讯作者: Schaeffter, Tobias

Evaluation of current algorithms for segmentation of scar tissue from late gadolinium enhancement cardiovascular magnetic resonance of the left atrium: an open-access grand challenge.

• DOI: 10.1186/1532-429x-15-105
• 发表时间: 2013-12-20
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Karim R;Housden RJ;Balasubramaniam M;Chen Z;Perry D;Uddin A;Al-Beyatti Y;Palkhi E;Acheampong P;Obom S;Hennemuth A;Lu Y;Bai W;Shi W;Gao Y;Peitgen HO;Radau P;Razavi R;Tannenbaum A;Rueckert D;Cates J;Schaeffter T;Peters D;MacLeod R;Rhode K
• 通讯作者: Rhode K

MRI-Compatible Intensity-Modulated Force Sensor for Cardiac Catheterization Procedures

• DOI: 10.1109/tbme.2010.2095853
• 发表时间: 2011-03-01
• 期刊: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
• 影响因子: 4.6
• 作者: Polygerinos, Panagiotis;Ataollahi, Asghar;Althoefer, Kaspar
• 通讯作者: Althoefer, Kaspar

Accelerated 3D catheter visualization from triplanar MR projection images.

从三平面 MR 投影图像加速 3D 导管可视化。

• DOI: 10.1002/mrm.22370
• 发表时间: 2010
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Schirra CO