MEDIC ONE STROKE SCALE

医生一搏量表

• 批准号: 6529070
• 负责人: DAVID L TIRSCHWELL
• 金额: $ 12.5万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529070
• 关键词: artificial intelligence; automated medical record system; brain disorder chemotherapy; cerebral hemorrhage; cerebral ischemia /hypoxia; cerebrovascular disorder diagnosis; clinical research; diagnosis quality /standard; disease /disorder classification; disease /disorder onset; early diagnosis; health care service evaluation; health care transport service; health services research tag; hospital utilization; human subject; human therapy evaluation; longitudinal human study; outcomes research; plasminogen activator; prognosis; rapid diagnosis; stroke; telecommunications; training

As stroke therapies emerge, they will likely work better if given earlier after stroke onset. This Patient-oriented Research Career Development Award proposal involves the design, implementation and validation of a prehospital stroke scale, the Medic One Stroke Scale (MOSS), with Dr. David Tirschwell as the principal investigator. Dr. Tirschwell is a neurologist completing a Master's degree in epidemiology at the University of Washington and plans a career as a stroke clinical researcher and epidemiologist. He will further his research training through study of issues surrounding the creation and validation of clinical measurement tools. Dr. Tirschwell has been studying the prehospital care of stroke patients in Seattle, Washington in collaboration with members of the Departments of Neurology and Epidemiology and Seattle Medic One (fire department). The hypothesis is that this continued collaboration can produce a rapid, reliable, easy to use stroke evaluation tool for the prehospital setting that will facilitate accurate identification and efficient transport times for acute stroke patients. A further hypothesis is that with this same tool, one can provide a useful early measure of stroke severity. Two versions of the MOSS will be created, a cohort of patients evaluated with each, and Dr. Tirschwell will examine the patients at a 3-month follow-up visit to determine outcomes. The first version (prediction) will record historical and clinical variables and evaluation and transport times. The shorter second version (validation), incorporating only the most predictive variables, will be associated with diagnosis and triage algorithms to minimize transport time for the most urgent stroke cases. The ease of use, reliability and predictive value of the MOSS will be validated in the second cohort and compared with the Glasgow Coma Scale and medical record abstracted NIHSS. Diagnostic accuracy, transport times, proportion of ischemic stroke patients receiving tPA and outcomes will be compared between the first and second cohorts. As stroke therapeutic research moves into the prehospital setting, the MOSS will serve as a standardized evaluation tool allowing early and accurate stroke diagnosis and severity stratification.

随着中风治疗的出现，如果在中风发作后早期给予，它们可能会更好地发挥作用。 这项以患者为导向的研究职业发展奖提案涉及院前卒中量表的设计、实施和验证，即Medic One Stroke Scale（MOSS），由大卫·蒂尔施韦尔博士担任首席研究员。 Tirschwell博士是一名神经学家，在华盛顿大学获得流行病学硕士学位，并计划成为中风临床研究员和流行病学家。 他将通过研究围绕临床测量工具的创建和验证的问题来进一步进行研究培训。 Tirschwell博士一直在与神经病学和流行病学部门以及西雅图医疗一号（消防部门）的成员合作，研究华盛顿州西雅图中风患者的院前护理。假设是，这种持续的合作可以产生一个快速，可靠，易于使用的中风评估工具，为院前设置，将有助于准确识别和有效的运输时间为急性中风患者。 另一个假设是，使用相同的工具，可以提供有用的中风严重程度的早期测量。 将创建两个版本的MOSS，每个版本都对一组患者进行评估，Tirschwell博士将在3个月的随访中对患者进行检查，以确定结果。 第一个版本（预测）将记录历史和临床变量以及评价和运输时间。 较短的第二个版本（验证），仅包含最具预测性的变量，将与诊断和分诊算法相关联，以最大限度地减少最紧急中风病例的运输时间。 将在第二个队列中验证MOSS的易用性、可靠性和预测价值，并与格拉斯哥昏迷量表和病历摘要NIHSS进行比较。 将比较第一和第二队列的诊断准确性、转运时间、接受tPA治疗的缺血性卒中患者比例和结局。随着卒中治疗研究进入院前环境，MOSS将作为标准化评估工具，允许早期和准确的卒中诊断和严重程度分层。