UW Medicine NINDS Stroke Trials Network Regional Coordinating Stroke Center

描述（由申请人提供）：该提案将创建华盛顿州中风试验网络（WA-STN），华盛顿大学中风中心（HMC）作为区域协调中心（UW-RCC）。David Tirschwell博士将担任PD/PI，他是华盛顿大学神经病学副教授、经委员会认证的血管神经科医生、中风护理领域公认的地区领导者和Harborview综合中风护理医学主任。十多年来，华盛顿大学的研究人员一直在进行美国国立卫生研究院和行业资助的中风研究，包括临床试验，包括SPSS， FIA， GOCHA， RESPECT， POINT， SHINE， TIPS, HI-DEF， CHS和MESA。我们的UW-RCC协调员在中风研究方面拥有丰富的经验，并且非常有资格与WA-STN医院进行对接，以确保快速启动（由中央IRB和主试验协议促进）和最高质量的试验执行。WA-STN将由16家不同规模的医院组成（包括2家儿童医院和UW telest卒中合作伙伴的小型医院），主要位于华盛顿西部，根据2011年医院数据，约有5,732名中风或TIA患者（17%非白种人，11%西班牙裔），足够的数量和种类满足试验招募目标。UW- rcc将围绕核心运营委员会组织，以促进快速启动，监测站点并与NCC/DMC/NINDS进行交互，WA-STN指导委员会讨论试验和进展并分享最佳临床和研究实践，以及咨询委员会（由UW和STN研究人员组成的多元化小组，具有卓越的中风专业知识），其成员可就研究设计的基础科学或临床方面提供当地或全国建议。担任审判的地方检察官，并担任

DESCRIPTION (provided by applicant): This proposal will create a Washington State Stroke Trials Network (WA-STN) with the University of Washington Stroke Center at Harborview (HMC) serving as the Regional Coordinating Center (UW-RCC). Dr. David Tirschwell, UW Associate Professor of Neurology, a board certified Vascular Neurologist, a recognized regional leader in stroke care and Medical Director for Comprehensive Stroke Care at Harborview, will be the PD/PI. UW investigators have been conducting NIH and industry funded stroke research, including clinical trials, for more than a decade, including SPSS, FIA, GOCHA, RESPECT, POINT, SHINE, TIPS, HI-DEF, CHS and MESA. Our UW-RCC coordinators have tremendous experience in stroke research, and are well qualified to interface with WA-STN hospitals to ensure rapid start up (facilitated by a central IRB and Master Trial Agreements) and highest quality execution of trials. The WA-STN will be comprised of 16 hospitals of varying sizes (including 2 children's hospitals and smaller hospitals that are UW TeleStroke partners), mostly in western Washington, who based on 2011 hospital data represent ~5,732 patients with stroke or TIA (17% non-Caucasian, 11% Hispanic), an adequate number and variety to meet trial enrollment goals. The UW-RCC will be organized around a core Operations Committee to facilitate rapid start-up, monitor sites and interface with the NCC/DMC/NINDS, a WA-STN Steering Committee to discuss trials and progress and share best clinical and research practices and an Advisory Committee (a diverse group of UW and STN researchers with remarkable stroke expertise) whose members are available to advise locally or nationally on basic science or clinical aspects of study design, to serve as local-Pis for trials and to serve as mentors for the stroke research fellow. WA-STN meetings and HMC monthly stroke education webcasts will be key to dissemination of network progress and results. Dr. Tirschwell is also Program Director for the HMC based ACGME Vascular Neurology fellowship, so is well suited to provide mentoring and access to a broad array of research and educational resources (many of which are available and strengthened through the UW CTSA) and expert mentors for our annual stroke research fellow.