UW Medicine NINDS Stroke Trials Network Regional Coordinating Stroke Center

华盛顿大学医学院 NINDS 卒中试验网络区域卒中协调中心

• 批准号: 8662488
• 负责人: DAVID L TIRSCHWELL
• 金额: $ 38.61万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8662488
• 关键词: Address; Advisory Committees; Agreement; Basic Science; Blood Vessels; Caring; Cause of Death; Clinical; Clinical Research; Clinical Trials; Commit; Contract Services; Data; Decision Making; Development; Development Plans; Disease; Enrollment; Ensure; Faculty; Fellowship; Funding; Goals; Hispanics; Hospitals; Incentives; Industry; Institution; Institutional Review Boards; International; Leadership; Medical center; Medicine; Mentors; Metric; Monitor; Multimedia; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Northwestern United States; Patient Education; Patients; Pediatric Hospitals; Pediatric Neurology; Physician Executives; Process; Progress Reports; Public Health; Qualifying; Quality of Care; Rehabilitation therapy; Research; Research Design; Research Infrastructure; Research Personnel; Research Training; Residencies; Resources; Rewards; Secondary Prevention; Series; Severities; Site; Specialist; Stroke; Stroke prevention; Teleconferences; Training; Training Programs; Travel; United States; United States National Institutes of Health; Universities; Visit; Washington; Work; acute stroke; base; career development; design; effective therapy; evidence base; experience; flexibility; improved; interest; lectures; medical specialties; meetings; member; multidisciplinary; next generation; operation; professor; programs; public health relevance; stroke education; stroke recovery; success; symposium

DESCRIPTION (provided by applicant): This proposal will create a Washington State Stroke Trials Network (WA-STN) with the University of Washington Stroke Center at Harborview (HMC) serving as the Regional Coordinating Center (UW-RCC). Dr. David Tirschwell, UW Associate Professor of Neurology, a board certified Vascular Neurologist, a recognized regional leader in stroke care and Medical Director for Comprehensive Stroke Care at Harborview, will be the PD/PI. UW investigators have been conducting NIH and industry funded stroke research, including clinical trials, for more than a decade, including SPSS, FIA, GOCHA, RESPECT, POINT, SHINE, TIPS, HI-DEF, CHS and MESA. Our UW-RCC coordinators have tremendous experience in stroke research, and are well qualified to interface with WA-STN hospitals to ensure rapid start up (facilitated by a central IRB and Master Trial Agreements) and highest quality execution of trials. The WA-STN will be comprised of 16 hospitals of varying sizes (including 2 children's hospitals and smaller hospitals that are UW TeleStroke partners), mostly in western Washington, who based on 2011 hospital data represent ~5,732 patients with stroke or TIA (17% non-Caucasian, 11% Hispanic), an adequate number and variety to meet trial enrollment goals. The UW-RCC will be organized around a core Operations Committee to facilitate rapid start-up, monitor sites and interface with the NCC/DMC/NINDS, a WA-STN Steering Committee to discuss trials and progress and share best clinical and research practices and an Advisory Committee (a diverse group of UW and STN researchers with remarkable stroke expertise) whose members are available to advise locally or nationally on basic science or clinical aspects of study design, to serve as local-Pis for trials and to serve as mentors for the stroke research fellow. WA-STN meetings and HMC monthly stroke education webcasts will be key to dissemination of network progress and results. Dr. Tirschwell is also Program Director for the HMC based ACGME Vascular Neurology fellowship, so is well suited to provide mentoring and access to a broad array of research and educational resources (many of which are available and strengthened through the UW CTSA) and expert mentors for our annual stroke research fellow.

描述（由申请人提供）：该提案将创建一个华盛顿州卒中试验网络 (WA-STN)，并将华盛顿大学卒中中心 (HMC) 作为区域协调中心 (UW-RCC)。 David Tirschwell 博士将担任 PD/PI，他是威斯康星大学神经病学副教授、委员会认证的血管神经学家、中风护理领域公认的地区领导者和 Harborview 综合中风护理医疗总监。十多年来，华盛顿大学的研究人员一直在进行 NIH 和行业资助的中风研究，包括临床试验，包括 SPSS、FIA、GOCHA、RESPECT、POINT、SHINE、TIPS、HI-DEF、CHS 和 MESA。我们的 UW-RCC 协调员在中风研究方面拥有丰富的经验，并且有资格与 WA-STN 医院联系，以确保快速启动（由中央 IRB 和主试验协议促进）和最高质量的试验执行。 WA-STN 将由 16 家不同规模的医院组成（包括 2 家儿童医院和 UW TeleStroke 合作伙伴的小型医院），大部分位于华盛顿州西部，根据 2011 年医院数据，这些医院约有 5,732 名中风或 TIA 患者（17% 非白人，11% 西班牙裔），数量和种类足以满足试验入组目标。 UW-RCC 将围绕一个核心运营委员会进行组织，以促进快速启动、监测站点以及与 NCC/DMC/NINDS 的联系；一个 WA-STN 指导委员会用于讨论试验和进展并分享最佳临床和研究实践；以及一个咨询委员会（由具有卓越中风专业知识的 UW 和 STN 研究人员组成的多元化小组），其成员可以就研究设计的基础科学或临床方面向当地或全国提供建议，以作为 本地 Pi 进行试验并作为 中风研究员的导师。 WA-STN 会议和 HMC 每月卒中教育网络广播将是传播网络进展和结果的关键。 Tirschwell 博士还是基于 HMC 的 ACGME 血管神经病学奖学金的项目主任，因此非常适合为我们的年度中风研究员提供指导和获得广泛的研究和教育资源（其中许多资源可以通过 UW CTSA 获得和加强）和专家导师。