UW Medicine NINDS Stroke Trials Network Regional Coordinating Stroke Center

描述(由申请人提供)：该提案将创建一个华盛顿州卒中试验网络(WA-STN)，华盛顿大学港务局卒中中心(HMC)作为区域协调中心(UW-RCC)。密歇根大学神经学副教授David Tirschwell博士将担任PD/PI，他是董事会认证的血管神经学家，也是中风护理领域公认的地区领导者和Harborview的全面中风护理医务总监。十多年来，威斯康星大学的调查人员一直在进行NIH和行业资助的中风研究，包括临床试验，包括SPSS、FIA、Gocha、尊重、POINT、SHIRE、TIPS、HI-DEF、CHS和MESA。我们的UW-RCC协调员在卒中研究方面拥有丰富的经验，他们非常有资格与西澳-STN医院对接，以确保快速启动(由中央IRB和主试验协议促进)和最高质量的试验执行。WA-STN将由16家不同规模的医院组成(包括2家儿童医院和与华盛顿大学TeleStroke合作的较小医院)，主要位于华盛顿西部，根据2011年的医院数据，这些医院代表了约5732名中风或短暂性脑缺血发作患者(17%非高加索人，11%西班牙裔)，这一数量和种类足以满足试验登记目标。UW-RCC将围绕核心业务委员会组织，以促进快速启动，监测地点并与NCC/DMC/NINDS接口，Wa-STN指导委员会讨论试验和进展并分享最佳临床和研究实践，以及咨询委员会(具有卓越中风专业知识的UW和STN研究人员的不同团体)，其成员可在当地或全国范围内就研究设计的基础科学或临床方面提供建议，作为试验的当地PI 中风研究员的导师。Wa-STN会议和HMC每月中风教育网络广播将是传播网络进展和结果的关键。Tirschwell博士也是总部设在HMC的ACGME血管神经学研究员项目主任，因此非常适合为我们的年度中风研究员提供指导和访问广泛的研究和教育资源(其中许多资源可通过UW CTSA获得并得到加强)和专家导师。

DESCRIPTION (provided by applicant): This proposal will create a Washington State Stroke Trials Network (WA-STN) with the University of Washington Stroke Center at Harborview (HMC) serving as the Regional Coordinating Center (UW-RCC). Dr. David Tirschwell, UW Associate Professor of Neurology, a board certified Vascular Neurologist, a recognized regional leader in stroke care and Medical Director for Comprehensive Stroke Care at Harborview, will be the PD/PI. UW investigators have been conducting NIH and industry funded stroke research, including clinical trials, for more than a decade, including SPSS, FIA, GOCHA, RESPECT, POINT, SHINE, TIPS, HI-DEF, CHS and MESA. Our UW-RCC coordinators have tremendous experience in stroke research, and are well qualified to interface with WA-STN hospitals to ensure rapid start up (facilitated by a central IRB and Master Trial Agreements) and highest quality execution of trials. The WA-STN will be comprised of 16 hospitals of varying sizes (including 2 children's hospitals and smaller hospitals that are UW TeleStroke partners), mostly in western Washington, who based on 2011 hospital data represent ~5,732 patients with stroke or TIA (17% non-Caucasian, 11% Hispanic), an adequate number and variety to meet trial enrollment goals. The UW-RCC will be organized around a core Operations Committee to facilitate rapid start-up, monitor sites and interface with the NCC/DMC/NINDS, a WA-STN Steering Committee to discuss trials and progress and share best clinical and research practices and an Advisory Committee (a diverse group of UW and STN researchers with remarkable stroke expertise) whose members are available to advise locally or nationally on basic science or clinical aspects of study design, to serve as local-Pis for trials and to serve as mentors for the stroke research fellow. WA-STN meetings and HMC monthly stroke education webcasts will be key to dissemination of network progress and results. Dr. Tirschwell is also Program Director for the HMC based ACGME Vascular Neurology fellowship, so is well suited to provide mentoring and access to a broad array of research and educational resources (many of which are available and strengthened through the UW CTSA) and expert mentors for our annual stroke research fellow.