QUANTITATIVE ANALYSIS OF OPTIC DISC/OCULAR HYPERTENSION

视盘/眼压的定量分析

• 批准号: 6384654
• 负责人: ROBERT N WEINREB
• 金额: $ 34.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6384654
• 关键词: African American; bioimaging /biomedical imaging; caucasian American; clinical research; cooperative study; diagnosis design /evaluation; glaucoma; glaucoma test; human subject; intraocular pressure; lasers; ophthalmoscopy; optic nerve; racial /ethnic difference; visual fields

This application describes a competitive renewal for an additional five years of funding for an ancillary study to the Ocular Hypertension Treatment Study (OHTS), a multicenter clinical trial sponsored by the National Eye Institute, to determine the effectiveness of confocal scanning laser ophthalmoscopy to objectively evaluate the optic disc in ocular hypertensive patients. The OHTS is currently funded through 2002. Specific Aims: 1. To evaluate the use of confocal scanning laser imaging techniques to detect glaucomatous optic nerve damage and change in ocular hypertensive patients. 2. To investigate the quantitative temporal relationship between optic nerve topography and measurable visual field loss. 3. To evaluate the effect of treatment on optic nerve topography. 4. To compare topographic optic disc parameters in African-American and White ocular hypertensive patients. Methods: Seven of the 21 OHTS study centers will participate in this ancillary study; 450 ocular hypertensive patients have consented to participate in the study. At least 389 (86 percent) are still active in the study; 137 (30 percent) have over 3 years of follow-up. Confocal laser scanning ophthalmoscopy is being used to measure optic disc and peripapillary topography at the randomization visit, and annually thereafter for the duration of the study. The Confocal Scanning Laser Ophthalmoscopy Reading Center at University of California, San Diego is responsible for processing and analyzing the images. The CSLO Reading Center provides the OHTS Data Coordinating Center with topographic optic disc data monthly. To ensure that this ancillary study will not jeopardize recruitment, retention, implementation of the primary trial or assessment of the primary findings, the reading center is masked to identity and treatment status of all patients. These data will be evaluated quantitatively for evidence of glaucomatous damage and change, and compared with other structural and functional measures of glaucomatous optic neuropathy obtained in the OHTS. This study will evaluate whether these advances in fundus imaging technology can improve the precision with which we can detect and monitor glaucomatous optic neuropathy.

本申请描述了一项额外五年资助的竞争性续期，用于眼高压治疗研究（OHTS）的辅助研究，这是一项由国家眼科研究所赞助的多中心临床试验，旨在确定共聚焦扫描激光检眼镜在客观评估眼高压患者视盘方面的有效性。职业健康服务计划目前的资助将持续到2002年。具体目标：1；目的探讨激光共聚焦扫描成像技术在青光眼视神经损伤及高眼压患者中的应用价值。2. 目的：探讨视神经地形与可测量视野损失的定量时间关系。3. 评价治疗对视神经地形的影响。4. 比较非裔美国人和白人高眼压患者的视盘参数。方法：21个OHTS研究中心中的7个将参与本辅助研究；已有450名高眼压患者同意参与这项研究。至少有389（86%）仍然活跃在这项研究中；137例（30%）随访超过3年。共聚焦激光扫描检眼镜被用于测量视盘和乳头周围的地形在随机访问，并在研究期间每年。加州大学圣地亚哥分校的共聚焦扫描激光眼科检查阅读中心负责处理和分析这些图像。CSLO阅读中心每月向OHTS数据协调中心提供地形光盘数据。为了确保该辅助研究不会危及主要试验的招募、保留、实施或主要研究结果的评估，阅读中心对所有患者的身份和治疗状态进行了保密。这些数据将被定量评估青光眼损伤和改变的证据，并与OHTS中获得的青光眼视神经病变的其他结构和功能测量进行比较。本研究将评估眼底成像技术的这些进步是否可以提高我们检测和监测青光眼视神经病变的精度。