Ophthalmology and Visual Sciences Career Development K12 Program

项目概要/摘要 加州大学圣地亚哥分校 NEI 指导临床科学家发展计划奖的总体目标是培养 杰出的临床科学家成功竞争 NIH 资助并成为学术界的领导者 眼科。通过这个机构职业发展奖，我们将继续指导临床医生 科学家们在眼科领域寻求独立的学术任命。自 1991 年以来，加州大学圣地亚哥分校 Shiley 眼科研究所在指导眼科临床科学家的职业发展方面表现出色。 其中许多人现在在世界各地拥有成功的研究和临床职业生涯；他们包括 系主任、处长和有影响力的院士。通过持续的资助，我们将扩大这些 通过结构化的指导、研究和教育计划来识别和指导下一个优势 跨越眼科所有亚专业领域的一代学术临床科学家。 重点是从女性和少数族裔申请者中招募强有力的申请者，学者们将 每年在完成眼科住院医师培训后临床研究金后都会被选中。学者 将在适合其科学重点的基础和/或临床科学领域开展这些活动， 并与导师合作以促进职业发展。每位学者都将接受临床培训 相关研究、统计、科学写作、拨款准备、道德、领导力和负责任的行为 研究。每位学者课程的其他方面将由项目主任进行个性化定制 (PI)、研究总监、教育总监、执行委员会、指导小组和首席导师 根据学者选择的主要研究方向以及他/她的技能、背景和职业目标。每个 学者将创建一个原创的研究项目，并通过该奖项发展一个独立的学术 职业生涯。 我们提出了六个主要研究方向：(1) 视觉神经科学，(2) 基因组学和蛋白质组学，(3) 生物工程、(4) 干细胞生物学、(5) 人工智能和信息学、(6) 临床（人类受试者） 研究。 在第一个 K12 资助期间，我们培训并招募了四名视网膜亚专业领域的临床科学家 (2)、青光眼 (1) 和小儿眼科 (1)。其中两名学者已获得 NIH K08 奖项，另外两个已提交K08提案正在考虑中。

PROJECT SUMMARY / ABSTRACT The overall objective of the NEI Mentored Clinical Scientist Development Program Award at UCSD is to develop outstanding clinician scientists to successfully compete for NIH grants and emerge as leaders within academic ophthalmology. Through this institutional career development award, we will continue to mentor clinician scientists toward independent academic appointments in ophthalmology. Since 1991, the UC San Diego Shiley Eye Institute has excelled in mentoring the career development of clinician scientists throughout ophthalmology. Many of these individuals now have successful research and clinical careers around the world; they include Department Chairs, Division Chiefs, and impactful academicians. With continued funding, we will amplify these strengths through a structured program of mentoring, research, and education to identify and mentor the next generation of academic clinician scientists, across all subspecialty areas of ophthalmology. With an emphasis on recruiting strong applications from women and minority applicants, Scholars will be selected each year after their completion of a post-residency clinical fellowship in ophthalmology. The Scholar will undertake these activities in the area of basic and/or clinical sciences appropriate to their scientific focus, and by partnering with mentor(s) to facilitate career development. Each Scholar will be trained in clinically relevant research, statistics, scientific writing, grant preparation, ethics, leadership, and the responsible conduct of research. Additional aspects of the curriculum of each Scholar will be individualized by the Program Director (PI), Research Directors, Education Director, Executive Committee, Mentoring Group, and lead mentor based upon the Scholar's selected primary research track and his/her skills, background, and career goals. Each Scholar will create an original research program and through this Award develop an independent academic career. We propose six primary research tracks: (1) Visual Neuroscience, (2) Genomics and Proteomics, (3) Bioengineering, (4) Stem Cell Biology, (5) Artificial Intelligence and Informatics, and (6) Clinical (human subjects) Research. In the first K12 funding period, we trained and recruited four clinician scientists in the subspecialty areas of retina (2), glaucoma (1), and pediatric ophthalmology (1). Two of these Scholars already have received NIH K08 awards, and the other two have submitted K08 proposals that are under consideration.