QUANTITATIVE ANALYSIS OF OPTIC DISC/OCULAR HYPERTENSION

视盘/眼压的定量分析

• 批准号: 2444380
• 负责人: ROBERT N WEINREB
• 金额: $ 20万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2444380
• 关键词: African American; cooperative study; glaucoma; glaucoma test; human subject; intraocular pressure; lasers; ophthalmoscopy; optic nerve; racial /ethnic difference; visual fields

This application describes an ancillary study to the Ocular Hypertension Treatment Study (OHTS), a multicenter clinical trial sponsored by the National Eye Institute, to determine the effectiveness of confocal scanning laser ophthalmoscopy to objectively evaluate the optic disc in ocular hypertensive patients. Specific Aims: 1. To evaluate the use of confocal scanning laser imaging techniques to detect glaucomatous optic nerve damage and change in ocular hypertensive patients. 2. To investigate the quantitative temporal relationship between optic nerve topography and measurable visual field loss. 3. To evaluate the effect of treatment on optic nerve topography. 4. To compare topographic optic disc parameters in African-American and white ocular hypertensive patients. Methods: Six of the 21 OHTS study centers will participate in this ancillary study; at least 400 ocular hypertensive patients will be included. Confocal laser scanning ophthalmoscopy will be used to measure optic disc and peripapillary topography at the randomization visit, and annually thereafter for the duration of the study. A Confocal Scanning Laser Ophthalmoscopy Reading Center will be established at University of California, San Diego to process and analyze the images. To ensure that this ancillary study will not jeopardize recruitment, retention, implementation of the primary trial or assessment of the primary findings, the reading center will be masked to identity and treatment status of all patients. These data will be evaluated quantitatively for evidence of glaucomatous damage and change, and compared with other structural and functional measures of glaucomatous optic neuropathy obtained in the OHTS. This study will evaluate whether these advances in fundus imaging technology can improve the precision with which we can detect and monitor glaucomatous optic neuropathy.

本申请描述了高眼压症的辅助研究 治疗研究（OHTS），一项由美国国立卫生研究院主办的多中心临床试验 国家眼科研究所，确定共焦的有效性 扫描激光检眼镜可客观评估视盘 高眼压患者。 具体目标： 1. 评估共焦扫描激光成像的使用 检测青光眼视神经损伤和眼部变化的技术 高血压患者。 2. 研究定量时间 视神经地形与可测量视野之间的关系 损失。 3.评估治疗对视神经地形的影响。 4. 比较非裔美国人和白人的视神经盘地形参数 高眼压患者。 方法：21 个 OHTS 研究中心中的 6 个将参与本次研究 辅助研究；至少400名高眼压患者 包括。共焦激光扫描检眼镜将用于测量 随机访视时的视盘和视乳头周围地形，以及 此后在研究期间每年一次。 共焦扫描 激光检眼镜阅片中心将在大学成立 加利福尼亚州圣地亚哥处理和分析图像。为了确保 这项辅助研究不会危及招募、保留、 实施初步试验或评估主要结果， 阅读中心将隐藏所有人的身份和治疗状况 患者。这些数据将被定量评估以作为证据 青光眼的损害和变化，以及与其他结构和变化的比较 在 OHTS 中获得的青光眼视神经病变的功能测量。 这项研究将评估眼底成像的这些进展是否 技术可以提高我们检测和监控的精度 青光眼性视神经病变。