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BARBADOS INCIDENCE STUDY OF EYE DISEASES II

巴巴多斯眼病发病率研究 II

基本信息

批准号：
6384590
负责人：
MCRISTINA LESKE
金额：
$ 85.23万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-09-30 至 2003-06-30
项目状态：
已结题

项目摘要

The proposed Barbados Incidence Study of Eye Diseases II (BISED II) aims to collect 9-year incidence and progression data on open-angle glaucoma (OAG) and age-related cataract in the predominantly black population of Barbados, West Indies, as well as to obtain natural history data on age- related macular changes and diabetic changes. OAG and cataract are the two major causes of blindness in populations of African origin, accounting for about half of visual loss. Despite their high prevalence and public health importance, data on blacks are limited and no clear explanation for the increased risk exists. Early macular changes were frequent in the BES. Although diabetic retinopathy was less common, about one-fifth of the population has diabetes, thus raising questions about risk factors for DR in a black population. BISED II provides a unique opportunity to obtain the first long term incidence and progression data on a large population- based cohort, as such longitudinal data are not available for black populations. BISED II will provide new information concerning natural history and underlying factors for these chronic, life-long eye diseases, to assist in understanding etiology, identifying groups at high risk, and developing strategies to control visual loss. A shorter follow-up is insufficient to provide this information. To achieve these aims, BISED II will re-examine the surviving cohort of the Barbados Eye Study (BES). The BES was conducted from 1988 to 1992 to measure prevalence and risk factors for OAG, cataract, age-related macular degeneration and diabetic retinopathy, while providing baseline data for further incidence measurements. The BES was followed by the Barbados Incidence Study of Eye Diseases (BISED; 1992-1997), which is determining 4-year incidence and progression for these conditions. High participation rates of 84% and 85% were achieved by BES and BISED, respectively, among the eligible cohort. The positive response of the cohort and the past experience gained in conducting BES and BISED enhance the feasibility of successful follow-up. Given the cohort size, follow-up rates of incidence and progression can be estimated with high precision. Given the high prevalence and incidence, a wide range of relative risks can be detected. In summary, the BES cohort is a unique resource to study the major causes of blindness and provides an opportunity to learn, for the first time, about their long-term patterns of occurrence in a black population. This information may assist to address major racial differences in prevalence and has important public health implications.

拟议的巴巴多斯眼病发病率研究II(BISED II)旨在收集开角型青光眼9年发病和进展资料 (OAG)和年龄相关性白内障在以黑人为主的巴巴多斯，西印度群岛，以及获得关于年龄的自然历史数据- 相关的黄斑改变和糖尿病改变。OAG和白内障是两个非洲裔人口失明的主要原因，占大约一半的视力丧失。尽管它们的高流行率和公共卫生重要的是，关于黑人的数据有限，也没有明确的解释风险增加是存在的。早期黄斑改变在BES中很常见。尽管糖尿病视网膜病变不太常见，但约五分之一的人们患有糖尿病，因此对DR的危险因素提出了质疑。在黑人人口中。BISED II提供了一个独特的机会第一个关于大量人口的长期发病和进展数据- 基于队列，因为这样的纵向数据不适用于黑人人口。BISED II将提供有关自然资源的新信息这些慢性终生眼病的病史和潜在因素，帮助了解病因，识别高危人群，以及制定控制视力损失的策略。一个更短的后续行动是不足以提供这方面的信息。为了实现这些目标，BISED II 将重新检查巴巴多斯眼科研究(BES)的幸存队列。这个 1988年至1992年进行了BES，以测量患病率和危险因素适用于OAG、白内障、老年性黄斑变性和糖尿病视网膜病变，同时提供进一步发病率的基线数据测量。BES之后是巴巴多斯的眼病发病率研究疾病(BISED；1992-1997年)，它正在确定4年发病率和这些情况的进展。84%和85%的高参与率分别由BES和BISED在合格队列中实现。队列的积极反应和过去在#年获得的经验进行BES和BISED提高了成功随访的可行性。考虑到队列大小，随访率和进展率可能是估计得很精确。鉴于高患病率和高发病率，可以检测到范围广泛的相对风险。总而言之，BES的队列是研究失明的主要原因的独特资源，并提供第一次有机会了解他们的长期在黑人群体中出现的模式。这一信息可能会对解决患病率的主要种族差异，并拥有重要的公众对健康的影响。