How material antibodies raised against receptors in the neonatal brain can give rise to antibody-mediated brain disporters

这个项目的主要目的是了解纹状体形成的发育过程和分子原理，纹状体是一种大脑结构，在许多神经发育障碍中受到影响，包括抽动症和强迫症，以及物质抗体在影响这一大脑结构的正常发育中的作用。这一发现研究的结果将提供对大脑发育的哪些方面对材料抗体暴露敏感的机械性见解，并为预防材料抗体介导的病理变化的新疗法提供理论基础。

The main aim of this project is to understand the developmental processes and molecular principles that underlie the formation of the striatum, a structure of the brain affected in many neurodevelopmental disorders including Tourette's syndrome and OCD, and the role of material antibodies in affecting the normal development of this brain structure. Outcomes of this discovery research will provide mechanistic insight into what aspects of brain development are sensitive to material antibody exposure and provide rationales for new therapies preventing material antibody-mediated pathologies.