How material antibodies raised against receptors in the neonatal brain can give rise to antibody-mediated brain disporters

针对新生儿大脑中的受体产生的物质抗体如何产生抗体介导的脑转运蛋白

• 批准号: 1404636
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1404636
• 关键词: How; material; antibodies; raised; against

The main aim of this project is to understand the developmental processes and molecular principles that underlie the formation of the striatum, a structure of the brain affected in many neurodevelopmental disorders including Tourette's syndrome and OCD, and the role of material antibodies in affecting the normal development of this brain structure. Outcomes of this discovery research will provide mechanistic insight into what aspects of brain development are sensitive to material antibody exposure and provide rationales for new therapies preventing material antibody-mediated pathologies.

该项目的主要目的是了解纹状体形成的发育过程和分子原理，纹状体是一种受许多神经发育障碍影响的大脑结构，包括图雷特综合征和强迫症，以及物质抗体在影响这种大脑结构正常发育中的作用。这一发现研究的结果将为大脑发育的哪些方面对物质抗体暴露敏感提供机制见解，并为预防物质抗体介导的病理的新疗法提供依据。