An Altered Peptide Ligand to Prevent Type 1 Diabetes

一种改变肽配体预防 1 型糖尿病

• 批准号: 6442763
• 负责人: JENNIFER B MARKS
• 金额: $ 25.51万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-29 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6442763
• 关键词: T lymphocyte; blood tests; cell population study; clinical trials; cooperative study; cytoprotection; diabetes mellitus therapy; disease /disorder prevention /control; disease /disorder proneness /risk; human subject; human therapy evaluation; immunologic assay /test; immunoregulation; insulin; insulin dependent diabetes mellitus; longitudinal human study; pancreatic islets; pathologic process; patient oriented research; statistics /biometry; stereoisomer; synthetic peptide; urinalysis

DESCRIPTION (provided by applicant) Type 1 diabetes mellitus occurs in genetically predisposed individuals as a consequence of the progressive, selective destruction of the pancreatic beta-cells mediated by autoreactive T-cells. Our long-range goals are to understand the natural history of Type 1 diabetes and to participate in the evaluation of potential new approaches to prevent or ameliorate this disease. The objectives of this application are threefold: 1) to complete the ongoing Diabetes Prevention Trial-Type 1 (DPT-1), 2) to be involved in the design and implementation of new intervention strategies and, 3) to propose a novel intervention strategy, to test the effects of an altered peptide ligand (APL), NBI-6024 (Neurocrine Biosciences), in individuals at risk for clinical Type 1 diabetes. The central hypothesis of this proposed study is that administration of this APL, containing two natural L-amino acid substitutions from the insulin B-chain (9-23) region, will temper the destructive autoimmune process leading to Type 1 diabetes, preserving beta-cells and their insulin-secreting capacity. The rationale for this study is that, if treatment with this APL is safe and effective at stopping or slowing disease progression in a population at defined risk, it could be tested at an earlier stage of diabetes development, in those with less well-defined risk, and possibly result in large-scale prevention. We will test the central hypothesis of our proposed study and accomplish the objectives as a TriaINet Clinical Center by pursuing the following three Specific Aims: 1. Complete the DPT-1 protocols and achieve their objectives, 2. Establish a network of collaborating investigators to participate in the design and conduct of future studies to evaluate new approaches to prevent or ameliorate Type 1 diabetes, 3. Evaluate the effects of intervention with an APL on progression to clinical diabetes in individuals at risk for Type 1 diabetes. It is our expectation that the DPT-1 protocols will be successfully completed, and that insulin administration will alter the destructive immune response in the beta-cells, and attenuate beta-cell autoimmunity, thereby preventing or delaying the development of Type 1 diabetes. The data collected will also better characterize the natural history of Type 1 diabetes disease development. It is also our expectation, based on our Clinical Center performance in the DPT-1, and on the expertise of our investigators, that our contribution to the Diabetes TriaINet will help to ensure its successful implementation and facilitate its functioning as envisioned in future intervention trials. Additionally, we will test the hypothesis that our innovative intervention plan based on the administration of APL NBI-6024 will prevent or reduce disease progression. If not prevented, a treatment effect that preserves beta-cell function in those who do develop diabetes will provide an important clinical benefit.

描述(由申请人提供) 1型糖尿病发生在遗传易感人群中，表现为 胰腺的渐进性选择性破坏的后果 由自身反应性T细胞介导的β细胞。我们的长期目标是 了解1型糖尿病的自然病史并参与 评估预防或改善这种疾病的潜在新方法。 此应用程序的目标有三个：1)完成正在进行的 糖尿病预防试验-1型(DPT-1)，2)参与设计和 实施新的干预策略，以及，3)提出新的 干预策略，以测试改变的多肽配体(APL)的效果， NBI-6024(神经分泌生物科学)，临床1型高危人群 糖尿病。这项拟议研究的中心假设是，政府 含有来自胰岛素的两个天然的L氨基酸取代 B链(9-23)区域，会缓和导致破坏性自身免疫的过程 对于1型糖尿病，保护β细胞和它们的胰岛素分泌能力。 这项研究的基本原理是，如果用这种APL治疗是安全的和 在规定的时间内有效地阻止或减缓人群中的疾病进展 风险，它可以在糖尿病发展的早期阶段进行测试，在 风险定义较少，并可能导致大规模预防。我们 将测试我们提议的研究的中心假设，并实现 作为TriaINet临床中心的目标包括以下三个方面 具体目标：1.完成DPT-1议定书并实现其目标，2. 建立合作调查人员网络，参与设计 并进行未来的研究，以评估预防或 改善1型糖尿病，3.评估APL干预的效果 1型糖尿病高危人群进展为临床糖尿病的研究。 我们期望DPT-1协议将成功完成， 注射胰岛素会改变体内的破坏性免疫反应 β细胞，并减弱β细胞自身免疫，从而防止或 延缓1型糖尿病的发展。收集的数据还将 更好地描述1型糖尿病疾病发展的自然历史。 这也是我们的期望，基于我们临床中心在 DPT-1，以及我们调查人员的专业知识，我们对 糖尿病TriaINet将有助于确保成功实施和 促进其按照未来干预试验的设想发挥作用。 此外，我们将测试我们的创新干预计划的假设 基于APL的服用NBI-6024将预防或减少疾病 进步。如果不加以预防，一种保护贝塔细胞的治疗效果 对于那些确实患有糖尿病的人来说，功能将提供一个重要的临床 利益。