PhD The development of Next-Gen Microfluidics and Bioinformatics approaches for the Characterisation of Superior Biopharmaceuticals

博士 下一代微流体和生物信息学方法的开发，用于表征优质生物制药

• 批准号: 1637263
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1637263
• 关键词: PhD; development; Next; Gen; Microfluidics

Although microfluidic analytics has been employed in small molecule medicine development, it has not been used for applications related to biopharmaceutical entities and processes. Also there are no bioinformatics tools available for predicting molecule behaviours during manufacturing and formulation development.This collaborative PhD project between UCL and GSK will aim to develop novel analytical approaches for monitoring the quality of biopharmaceuticals during bioprocess manufacturing. It will develop appropriate micro-scale technologies to meet the requirements of the modern biopharmaceutical development landscape. It will evaluate current analytical approaches in terms of sample requirements, sensitivity, throughput, requirement for sample preparation. It will then adapt the most promising techniques to bring it closer to a capability in automated online bioprocess monitoring. Finally, the project will use the datasets (built from the micro-scale technology) to support the design and development of computational tools and technologies with application to address the challenges outlined above.

虽然微流控分析已经被用于小分子药物的开发，但它还没有被用于与生物制药实体和过程相关的应用。此外，目前还没有生物信息学工具可用于预测制造和配方开发过程中的分子行为。UCL和GSK之间的这一合作博士项目旨在开发新的分析方法，用于在生物工艺制造过程中监控生物制药的质量。它将开发适当的微型技术，以满足现代生物制药发展格局的要求。它将从样品要求、灵敏度、吞吐量、样品制备要求等方面对目前的分析方法进行评估。然后，它将采用最有希望的技术，使其更接近自动化在线生物过程监测的能力。最后，该项目将使用数据集(从微尺度技术建立)来支持计算工具和技术的设计和开发，并将其应用于应对上述挑战。