FRONTAL LOBE PLASTICITY AFTER BRAIN INJURY IN CHILDHOOD
儿童期脑损伤后额叶的可塑性
基本信息
- 批准号:6343193
- 负责人:
- 金额:$ 8.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-01-01 至 2002-12-31
- 项目状态:已结题
- 来源:
- 关键词:adolescence (12-20) behavioral /social science research tag brain injury clinical research developmental neurobiology developmental psychology early experience frontal lobe /cortex functional ability gender difference human subject infant human (0-1 year) language development longitudinal human study memory disorders middle childhood (6-11) neural information processing neural inhibition neural plasticity neuropsychological tests perception disorder psychological adaptation psychophysiology sensory mechanism social adjustment
项目摘要
DESCRIPTION. Over recent years, it has become clear that the functional
plasticity of the brain following damage sustained in infancy varies
according to the functions being assessed and the anatomic areas affected by
the damage. Although out understanding of the effect of early damage on
language and visuospatial functions has increased greatly, studies of the
executive functions normally associated with the frontal lobes, such as
planning, problem solving, working memory and inhibition, have not been done
with children who sustained early focal brain injury. Such research has the
potential to provide information regarding the degree of functional
plasticity of prefrontal cortex. By specifically looking for dissociations
among aspects of informational processing hypothesized to underlie more
complex frontal behaviors, this study also proposes to examine the
separability of these functions in development and whether they are
specifically related to distinct areas of the frontal lobes as has been seen
in adults. A further goal of the study is to investigate whether damage to
frontal areas is associated with greater developmental disabilities in
adaptive and social functions than damage to posterior areas.
These goals will be accomplished by comparing a group of children with
unilateral, focal brain lesions sustained prior to 6 months of age with
normally developing controls on a battery of executive functioning measures.
Dissociations on specific measures of working memory and inhibitory
functioning will be examined within the focal lesion group as well as within
normally developing controls. Finally, the relationship of performance on
these measures to social and adaptive functioning will be examined.
说明. 近年来,人们已经清楚地认识到,
在婴儿期受到损伤后,大脑的可塑性
根据被评估的功能和受影响的解剖区域,
造成的伤害 虽然我们不了解早期损伤对
研究表明,语言和视觉空间功能大大增强
通常与额叶相关的执行功能,例如
计划、问题解决、工作记忆和抑制,尚未完成
患有早期局灶性脑损伤的儿童 这样的研究有
提供有关功能性程度的信息的潜力
前额叶皮层的可塑性 通过专门寻找
在信息处理的各个方面中,
复杂的正面行为,这项研究还提出,检查
这些功能在发展中的可分离性,以及它们是否
特别是与额叶的不同区域有关,
在成年人中。 这项研究的另一个目标是调查是否损害
额叶与更大的发育障碍有关,
适应和社会功能比后部区域的损害更大。
这些目标将通过比较一组儿童与
单侧局灶性脑损伤持续到6个月龄之前,
通常对一系列执行功能措施进行控制。
工作记忆和抑制性记忆的具体措施的分离
将在局灶性病变组以及
正常发展控制。 最后,分析了绩效与
将对这些社会和适应功能的措施进行审查。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SHARON L NICHOLS其他文献
SHARON L NICHOLS的其他文献
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{{ truncateString('SHARON L NICHOLS', 18)}}的其他基金
Defining intervention targets along pathways from cumulative stress and trauma to alcohol and HIV self-management among young people living with HIV (Project DEFINE)
沿着从累积压力和创伤到青少年艾滋病毒感染者酒精和艾滋病毒自我管理的路径确定干预目标(项目定义)
- 批准号:
10304697 - 财政年份:2021
- 资助金额:
$ 8.84万 - 项目类别:
Defining intervention targets along pathways from cumulative stress and trauma to alcohol and HIV self-management among young people living with HIV (Project DEFINE)
沿着从累积压力和创伤到青少年艾滋病毒感染者酒精和艾滋病毒自我管理的路径确定干预目标(项目定义)
- 批准号:
10678996 - 财政年份:2021
- 资助金额:
$ 8.84万 - 项目类别:
Memory Functioning in Children and Adolescents with Perinatal HIV Infection
围产期艾滋病毒感染儿童和青少年的记忆功能
- 批准号:
8197402 - 财政年份:2009
- 资助金额:
$ 8.84万 - 项目类别:
Memory Functioning in Children and Adolescents with Perinatal HIV Infection
围产期艾滋病毒感染儿童和青少年的记忆功能
- 批准号:
7845398 - 财政年份:2009
- 资助金额:
$ 8.84万 - 项目类别:
Memory Functioning in Children and Adolescents with Perinatal HIV Infection
围产期艾滋病毒感染儿童和青少年的记忆功能
- 批准号:
8369331 - 财政年份:2009
- 资助金额:
$ 8.84万 - 项目类别:
Memory Functioning in Children and Adolescents with Perinatal HIV Infection
围产期艾滋病毒感染儿童和青少年的记忆功能
- 批准号:
8582564 - 财政年份:2009
- 资助金额:
$ 8.84万 - 项目类别:
Memory Functioning in Children and Adolescents with Perinatal HIV Infection
围产期艾滋病毒感染儿童和青少年的记忆功能
- 批准号:
8006434 - 财政年份:2009
- 资助金额:
$ 8.84万 - 项目类别:
FRONTAL LOBE PLASTICITY AFTER BRAIN INJURY IN CHILDHOOD
儿童期脑损伤后额叶的可塑性
- 批准号:
2026197 - 财政年份:1997
- 资助金额:
$ 8.84万 - 项目类别:
FRONTAL LOBE PLASTICITY AFTER BRAIN INJURY IN CHILDHOOD
儿童期脑损伤后额叶的可塑性
- 批准号:
6138802 - 财政年份:1997
- 资助金额:
$ 8.84万 - 项目类别:
FRONTAL LOBE PLASTICITY AFTER BRAIN INJURY IN CHILDHOOD
儿童期脑损伤后额叶的可塑性
- 批准号:
2857474 - 财政年份:1997
- 资助金额:
$ 8.84万 - 项目类别: