Memory Functioning in Children and Adolescents with Perinatal HIV Infection

围产期艾滋病毒感染儿童和青少年的记忆功能

• 批准号: 8582564
• 负责人: SHARON L NICHOLS
• 金额: $ 39.3万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-18 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8582564
• 关键词: AIDS neuropathy; AIDS/HIV problem; Academic achievement; Adaptive Behaviors; Adherence; Adolescence; Adolescent; Adult; Affect; Age; Anti-Retroviral Agents; Area; Attention; Behavior; Behavioral; Birth; Brain; Caregivers; Caring; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Chronic Disease; Clinical Sciences; Cognitive; Cohort Studies; Communities; Complex; Data; Development; Diagnosis; Disease; Disease Marker; Failure; Future; Generations; Goals; HIV; HIV Infections; HIV-1; Health; Healthcare; Impairment; Infection; Intention; Intervention; Investigation; Knowledge; Language; Learning; Life; Literature; Longevity; Longitudinal Studies; Mathematics; Measures; Medical; Medication Management; Memory; Mosses; Neuraxis; Neurocognitive; Occupational; Outcome; Parents; Pattern; Performance; Perinatal; Perinatal Infection; Persons; Pharmaceutical Preparations; Population; Problem Solving; Protocols documentation; Provider; Public Health; Quality of life; Reading; Recording of previous events; Relative (related person); Research; Research Design; Resistance; Resources; Risk; Sampling; Self Care; Severities; Severity of illness; Short-Term Memory; Site; Task Performances; Testing; Time; Underserved Population; Viral; Virus; Youth; advanced disease; base; coping; cost effective; daily functioning; design; economic implication; effective intervention; executive function; falls; flexibility; functional outcomes; health economics; improved functioning; insight; longitudinal design; medication compliance; meetings; neuropathology; pediatric human immunodeficiency virus infection; peer; physical conditioning; prospective memory; skills; social; social skills; therapy development; tool; young adult

DESCRIPTION (provided by applicant): Current treatments have transformed HIV/AIDS from an inevitably fatal disease to one commonly managed as a chronic illness. Many children born with HIV infection, who previously suffered brief life spans, are now surviving into adulthood. This creates the need to understand more fully the obstacles these youth encounter in becoming independent, productive adults. In adults, HIV commonly is associated with impairments in memory and executive functions (such as inhibition, cognitive flexibility, and problem solving), which increase the risk of problems in day-to-day functioning, including medication nonadherence. Studies of memory and executive functions in children and youth with HIV infection are extremely limited, however, and none have included measures of prospective memory (that is, the ability to execute a future intention), which is a particularly robust predictor of daily functioning in adults with HIV. Furthermore, our current understanding of the functional impact of HIV on brain development is limited. The study proposed here would be the first to evaluate the complex interplay between development and HIV infection on memory and executive functions in the context of important functional outcomes in an effort to advance the clinical science of pediatric neuroAIDS. The study will test the hypotheses that: 1) perinatally acquired HIV is associated with deficits in memory and executive functioning; 2) HIV severity and history, including age at greatest disease severity, will be associated with degree of impairment in memory and executive functioning ; 3) developmental change and changes in HIV severity will interact to influence these functions over time; and 4) impairments in memory and executive function contribute to problems in daily functioning (including medication adherence, academic achievement, and adaptive behavior). Using a longitudinal design to examine and control for developmental changes in these functions during adolescence, we will administer measures of verbal and nonverbal retrospective memory, prospective memory, executive functions, and medication adherence to 200 HIV-infected and 75 uninfected youth age 9-18 at two time points, two years apart. Data will be collected at eight sites participating in a large national, longitudinal study of outcomes of perinatal HIV infection, the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol, thus allowing us to examine memory and executive functioning in an efficient and cost-effective manner in the larger context of demographic, health-related, cognitive, and behavioral aspects of perinatal HIV infection. This is an important area for investigation because deficits in memory and executive function in youth with HIV could have wide-ranging effects on their acquisition of health and medication management skills, adaptive and academic functioning, behavior, and, ultimately, social and occupational outcome in adulthood. We anticipate this study will not only elucidate developmental neurocognitive aspects of perinatally acquired HIV but will also provide important information and additional tools to target areas of intervention for perinatally HIV-infected youth at risk for poor functional outcomes.

DESCRIPTION (provided by applicant): Current treatments have transformed HIV/AIDS from an inevitably fatal disease to one commonly managed as a chronic illness. Many children born with HIV infection, who previously suffered brief life spans, are now surviving into adulthood. This creates the need to understand more fully the obstacles these youth encounter in becoming independent, productive adults. In adults, HIV commonly is associated with impairments in memory and executive functions (such as inhibition, cognitive flexibility, and problem solving), which increase the risk of problems in day-to-day functioning, including medication nonadherence. Studies of memory and executive functions in children and youth with HIV infection are extremely limited, however, and none have included measures of prospective memory (that is, the ability to execute a future intention), which is a particularly robust predictor of daily functioning in adults with HIV. Furthermore, our current understanding of the functional impact of HIV on brain development is limited. The study proposed here would be the first to evaluate the complex interplay between development and HIV infection on memory and executive functions in the context of important functional outcomes in an effort to advance the clinical science of pediatric neuroAIDS. The study will test the hypotheses that: 1) perinatally acquired HIV is associated with deficits in memory and executive functioning; 2) HIV severity and history, including age at greatest disease severity, will be associated with degree of impairment in memory and executive functioning ; 3) developmental change and changes in HIV severity will interact to influence these functions over time; and 4) impairments in memory and executive function contribute to problems in daily functioning (including medication adherence, academic achievement, and adaptive behavior). Using a longitudinal design to examine and control for developmental changes in these functions during adolescence, we will administer measures of verbal and nonverbal retrospective memory, prospective memory, executive functions, and medication adherence to 200 HIV-infected and 75 uninfected youth age 9-18 at two time points, two years apart. Data will be collected at eight sites participating in a large national, longitudinal study of outcomes of perinatal HIV infection, the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol, thus allowing us to examine memory and executive functioning in an efficient and cost-effective manner in the larger context of demographic, health-related, cognitive, and behavioral aspects of perinatal HIV infection. This is an important area for investigation because deficits in memory and executive function in youth with HIV could have wide-ranging effects on their acquisition of health and medication management skills, adaptive and academic functioning, behavior, and, ultimately, social and occupational outcome in adulthood. We anticipate this study will not only elucidate developmental neurocognitive aspects of perinatally acquired HIV but will also provide important information and additional tools to target areas of intervention for perinatally HIV-infected youth at risk for poor functional outcomes.

项目成果

Learning and Memory in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure.

• DOI: 10.1097/inf.0000000000001131
• 发表时间: 2016-06
• 期刊: The Pediatric infectious disease journal
• 作者: Nichols SL;Chernoff MC;Malee K;Sirois PA;Williams PL;Figueroa V;Woods SP;Memory and Executive Functioning Substudy of the Pediatric HIVAIDS Cohort Study
• 通讯作者: Memory and Executive Functioning Substudy of the Pediatric HIVAIDS Cohort Study

Impact of Perinatally Acquired HIV Disease Upon Longitudinal Changes in Memory and Executive Functioning.

• DOI: 10.1097/qai.0000000000001441
• 发表时间: 2017-08-01
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Malee KM;Chernoff MC;Sirois PA;Williams PL;Garvie PA;Kammerer BL;Harris LL;Nozyce ML;Yildirim C;Nichols SL;Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study
• 通讯作者: Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study

The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).

药房补充措施在评估围产期获得性 HIV (PHIV) 青少年的依从性和预测 HIV 疾病标志物方面的作用。

• DOI: 10.1007/s10461-019-02468-x
• 发表时间: 2019
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Yildirim,Cenk;Garvie,PatriciaA;Chernoff,Miriam;Wilkins,MeganL;Patton,EDoyle;Williams,PaigeL;Nichols,SharonL;MemoryandExecutiveFunctioningStudyofthePediatricHIV/AIDSCohortStudy
• 通讯作者: MemoryandExecutiveFunctioningStudyofthePediatricHIV/AIDSCohortStudy