Dynamic action potential clamp studies of drugs that affect the cardiac action potential

影响心脏动作电位药物的动态动作电位钳研究

• 批准号: nhmrc : 1047506
• 负责人: Dr Stefan Mann
• 金额: $ 22.94万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dynamic-action-potential-action-potential/111941
• 关键词: Dynamic; action; potential; clamp; studies

The development of drugs to treat and.or prevent cardiac arrhythmias have been plagued by the side-effect of actually increasing the risk of sudden death. One of the reasons for this is that drugs that work well in one part of the heart may cause problems in another part. We are developing a system called “dynamic action potential clamp” that will make it easier for researchers to assess the effect of drugs in different regions of both normal and diseased hearts.

治疗和/或预防心律失常的药物的开发一直受到实际上增加猝死风险的副作用的困扰。其中一个原因是，药物在心脏的一个部分工作良好，可能会导致另一个部分的问题。我们正在开发一种称为“动态动作电位钳”的系统，这将使研究人员更容易评估药物在正常和患病心脏不同区域的作用。