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ENGINEERING POLYMERIC ARTIFICIAL CELLULAR ENVIROMENTS (PACES) FOR ADHESION AND QUORUM SENSING

设计用于粘附和群体感应的聚合物人工细胞环境 (PACES)

基本信息

批准号：
1644140
负责人：
金额：
--
依托单位：
University of Birmingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1644140
关键词：
ENGINEERING POLYMERIC ARTIFICIAL CELLULAR ENVIROMENTS

项目摘要

V. cholerae is the causative agent of cholera, a disease that affects 3-5 million people and causes 100,000-130,000 deaths/year. V. cholerae uses QS to control pathogenicity and the expression of virulence factors. Unlike many other pathogens, V. cholerae uses QS to repress virulence traits such as toxin production and host attachment. This way the pathogen coordinates host decolonization and environmental dissemination following infection. Small molecules designed to agonize QS result in repression of these virulence factors, compromising the ability of V. cholerae to colonise the host and cause acute diarrheal disease. However, this comes at the expense of increasing the ability of V. cholerae to spread to other hosts, compromising containment of the disease. It is therefore desirable to develop agents that inhibit the expression of the virulence factors while containing the pathogen, through clustering, and facilitating its mechanical removal from contaminated water, for instance. But to do this, we need to develop an understanding of how chemical functionality and material properties (e.g. molecular mass) affect the microbiology of the pathogen. In particular, we are interested in identifying how these materials properties can modulate the expression of relevant V. cholerae phenotypes, including those associated with virulence.

霍乱弧菌是霍乱的病原体，霍乱是一种影响300万至500万人的疾病，每年造成10万至13万人死亡。霍乱弧菌使用QS来控制致病性和毒力因子的表达。与许多其他病原体不同，霍乱弧菌使用QS抑制毒力性状，如毒素产生和宿主附着。通过这种方式，病原体在感染后协调宿主非殖民化和环境传播。设计用于激动QS的小分子导致这些毒力因子的抑制，损害霍乱弧菌定殖宿主并引起急性腹泻病的能力。然而，这是以增加霍乱弧菌传播到其他宿主的能力为代价的，损害了对疾病的遏制。因此，希望开发抑制毒力因子表达同时通过聚集包含病原体并促进其从例如污染水中机械去除的试剂。但要做到这一点，我们需要了解化学功能和材料特性（例如分子量）如何影响病原体的微生物学。特别是，我们有兴趣确定这些材料的特性如何调节相关的霍乱弧菌表型的表达，包括与毒力相关的表型。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Aggregation of Vibrio cholerae by Cationic Polymers Enhances Quorum Sensing but Overrides Biofilm Dissipation in Response to Autoinduction.

DOI：
10.1021/acschembio.8b00815
发表时间：
2018-10-19
期刊：
ACS chemical biology
影响因子：
4
作者：
Perez-Soto N;Creese O;Fernandez-Trillo F;Krachler AM
通讯作者：
Krachler AM

Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation

聚（Boc-丙烯酰肼）：温度和 RAFT 剂降解对其制备的重要性

DOI：
10.1039/c9py01222b
发表时间：
2019
期刊：
Polymer Chemistry
影响因子：
4.6
作者：
Creese O
通讯作者：
Creese O

Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification.

DOI：
10.1039/c7py00535k
发表时间：
2017-08-20
期刊：
Polymer chemistry
影响因子：
4.6
作者：
Crisan DN;Creese O;Ball R;Brioso JL;Martyn B;Montenegro J;Fernandez-Trillo F
通讯作者：
Fernandez-Trillo F