SEROTONIN AND SMOKING AND PSYCHOPATHOLOGY

描述：(申请人摘要) 严重精神病患者的烟草使用率高得不成比例。 精神障碍，如精神分裂症和情感障碍。据报道， 精神分裂症患者的吸烟率从74%到90%不等， 在重度抑郁症患者中，这一比例为45%-75%，而在 普通人口。不仅烟草的使用更加普遍，而且还会导致精神疾病 吸烟的患者也更有可能大量吸烟，使用高焦油 和尼古丁香烟，并且吸烟的时间比 普通人群中的吸烟者。如果相关的严重健康风险 随着吸烟在精神病人群中的预防，它是第一个 有必要对患者吸烟如此严重的原因有更深入的了解。 本研究的目的是研究5-羟色胺在心脏疾病中的作用。 调整患者的精神病理症状和吸烟 有严重的精神障碍。据预测，一种血清素 耗尽挑战将增加抑郁和吸烟的人数 抑郁症患者，同时减少阴性症状和吸烟 在精神分裂症患者中。结果将增进对 吸烟的神经化学和行为过程 设计行为和药物治疗方法的意义 精神病患者的烟草依赖。

DESCRIPTION: (Applicant's Abstract) Tobacco use is disproportionately high among those with severe psychiatric disorders, such as schizophrenia and affective disorders. The reported prevalence of smoking ranges from 74-90% among schizophrenic patients, to 45-75% among patients with major depression, as compared to 28% in the general population. Not only is tobacco use more prevalent, but psychiatric patients who smoke are also more likely to smoke heavily, to use high tar and nicotine cigarettes, and to have smoked for a longer period of time than smokers from the general population. If the serious health risks associated with smoking are to be prevented in the psychiatric population, it is first necessary to have a greater understanding of why patients smoke so heavily. The aim of this research is to study the involvement of serotonin in regulating psychopathologic symptoms and cigarette smoking among patients with major psychiatric disorders. The prediction is that a serotonin depletion challenge will increase depression and cigarette smoking among depressed patients, while decreasing negative symptoms and cigarette smoking among schizophrenic patients. Results will enhance understanding of the neurochemical and behavioral processes of cigarette smoking and will have implications for designing behavioral and pharmacologic treatments for tobacco dependence in psychiatric patients.