Clinical Research in Comorbid Diabetes and Depression
糖尿病和抑郁症共病的临床研究
基本信息
- 批准号:6895266
- 负责人:
- 金额:$ 12.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2007-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
An NIDDK K24 award is requested to provide support for Patrick J. Lustman, Ph.D., to enhance a program of research and mentoring in Comorbid Diabetes and Depression. Diabetes affects 16 million Americans. Another 21 million have impaired glucose tolerance and are at risk for developing type 2 diabetes (T2DM). Major depression more than doubles the risk of T2DM even after controlling for other risk factors. Major depression is also present in 20% of patients with existing diabetes (type 1 or type 2), is associated with hyperglycemia, and conveys a significantly increased risk for each of the major complications of the metabolic disorder. The overall goals of the applicant's research are: 1) to elucidate the mechanisms by which depression affects the risk course, and outcome of diabetes; and 2) to determine whether and how depression treatment may improve glycemic control and the long-term course of diabetes. The proposal describes the applicant's current research, some ideas for future studies, and the career development and mentoring activities that are planned over the 5-year interval of the K24. Two NIH (NIDDK)-supported trials are ongoing. One is to determine if maintenance antidepressant treatment in diabetes will prevent or delay depression recurrence and produce durable improvements in glycemic control. The second is to establish if treatment of prepartum depression in diabetes will improve glycemic control and thereby decrease maternal and neonatal morbidity. Trainees will engage in these projects, take didactic coursework in clinical investigation, and complete a research proposal over the two-year training interval. A series of career development activities (for the PI) are also described that include additional training in structural equation modeling using SAS, and training in performing and interpreting intravenous glucose tolerance tests using minimal model analysis. K24 support will provide the applicant with the protected time needed to determine the utility of depression treatment in the everyday management of those living with diabetes and, in the process, to increase the mentoring of beginning clinical investigators in behavioral diabetes.
请授予NIDDK K24奖,以支持帕特里克·J·卢斯特曼博士加强糖尿病和抑郁症共病的研究和指导计划。糖尿病影响着1600万美国人。另有2100万人糖耐量受损,有患2型糖尿病(T2 DM)的风险。即使在控制了其他危险因素后,重度抑郁症也会使患T2 DM的风险增加一倍以上。20%的现有糖尿病患者(1型或2型)也存在严重抑郁,与高血糖有关,并显著增加了代谢紊乱的每一种主要并发症的风险。申请者研究的总体目标是:1)阐明抑郁症影响糖尿病风险过程和结果的机制;2)确定抑郁症治疗是否以及如何改善血糖控制和糖尿病的长期病程。该建议书描述了申请者目前的研究,对未来研究的一些想法,以及在K24的5年间隔内计划的职业发展和指导活动。两项由美国国立卫生研究院(NIDDK)支持的试验正在进行中。一是确定糖尿病的维持性抗抑郁治疗是否能预防或延缓抑郁复发,并在血糖控制方面产生持久的改善。第二个是确定糖尿病产前抑郁的治疗是否会改善血糖控制,从而降低孕产妇和新生儿的发病率。学员将参与这些项目,参加临床研究的教学课程,并在两年的培训间隔内完成研究方案。还介绍了一系列职业发展活动(针对PI),包括使用SAS进行结构方程建模的额外培训,以及使用最小模型分析执行和解释静脉葡萄糖耐量测试的培训。K24 Support将为申请者提供必要的保护时间,以确定抑郁症治疗在糖尿病患者的日常管理中的效用,并在此过程中增加对行为糖尿病初学临床研究人员的指导。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Predictors of premature antidepressant discontinuation in functional gastrointestinal disorders.
功能性胃肠道疾病过早停用抗抑郁药的预测因素。
- DOI:10.1097/psy.0b013e318031391d
- 发表时间:2007
- 期刊:
- 影响因子:3.3
- 作者:Sayuk,GregoryS;Elwing,JillE;Lustman,PatrickJ;Clouse,RayE
- 通讯作者:Clouse,RayE
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PATRICK J LUSTMAN其他文献
PATRICK J LUSTMAN的其他文献
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{{ truncateString('PATRICK J LUSTMAN', 18)}}的其他基金
DEPRESSION AND INSULIN RESISTANCE IN TYPE 2 DIABETES
2 型糖尿病中的抑郁和胰岛素抵抗
- 批准号:
7603323 - 财政年份:2007
- 资助金额:
$ 12.2万 - 项目类别:
Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
使用胰岛素增敏剂改善抑郁症治疗效果
- 批准号:
7625990 - 财政年份:2007
- 资助金额:
$ 12.2万 - 项目类别:
Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
使用胰岛素增敏剂改善抑郁症治疗效果
- 批准号:
7302255 - 财政年份:2007
- 资助金额:
$ 12.2万 - 项目类别:
Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
使用胰岛素增敏剂改善抑郁症治疗效果
- 批准号:
7858495 - 财政年份:2007
- 资助金额:
$ 12.2万 - 项目类别:
Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
使用胰岛素增敏剂改善抑郁症治疗效果
- 批准号:
8067099 - 财政年份:2007
- 资助金额:
$ 12.2万 - 项目类别:
WELLBUTRIN FOR DEPRESSION IN DIABETIC PATIENTS
维布特林 (Wellbutrin) 治疗糖尿病患者抑郁症
- 批准号:
7377217 - 财政年份:2006
- 资助金额:
$ 12.2万 - 项目类别:
DEPRESSION AND INSULIN RESISTANCE IN TYPE 2 DIABETES
2 型糖尿病中的抑郁和胰岛素抵抗
- 批准号:
7377203 - 财政年份:2006
- 资助金额:
$ 12.2万 - 项目类别:
DEPRESSION ASSOCIATED INSULIN RESISTANCE IN AFRICAN-AMERICAN YOUTH
非裔美国青年的抑郁症与胰岛素抵抗有关
- 批准号:
7198770 - 财政年份:2005
- 资助金额:
$ 12.2万 - 项目类别:
WELLBUTRIN FOR DEPRESSION IN DIABETIC PATIENTS
维布特林 (Wellbutrin) 治疗糖尿病患者抑郁症
- 批准号:
7198734 - 财政年份:2005
- 资助金额:
$ 12.2万 - 项目类别:
DEPRESSION AND INSULIN RESISTANCE IN TYPE 2 DIABETES
2 型糖尿病中的抑郁和胰岛素抵抗
- 批准号:
7198715 - 财政年份:2005
- 资助金额:
$ 12.2万 - 项目类别:
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