DIET, ESTROGEN, AND INTERNATIONAL CANCER INCIDENCE

这项建议的目的是确定饮食、雌激素代谢和乳腺癌之间的联系。这将涉及与法国里昂国际癌症研究机构营养与癌症部门的研究人员合作，开展欧洲癌症与营养前瞻性调查(EPIC)，这是一项针对9个国家48万人的大型前瞻性研究。具体假设是：1)特定雌激素代谢物(16a和4羟基代谢物)血浆浓度增加的女性患乳腺癌和其他生殖道癌的风险增加；2)特定食物的消费与16α和4羟基雌激素血浆浓度降低和生殖道癌风险降低有关；3)雌激素代谢物血浆浓度与雌激素代谢相关酶的遗传多态有关。这项研究可能会确定新的癌症风险生物标记物，可以用来识别高危女性，并制定预防癌症的饮食和生活方式策略。

The purpose of this proposal is to determine the associations among dietary, estrogen metabolism, and breast cancer. This will involve collaboration with researchers in the Nutrition and Cancer Unit of the International Agency for Research on Cancer in Lyon, France, on the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective study of 480,000 people in nine countries. The specific hypotheses are: 1) women with increased plasma concentrations of specific estrogen metabolites (16a and 4 hydroxy metabolites) are at increased risk of breast cancer and other cancers of the reproductive tract; 2) consumption of specific foods is associated with reduced plasma concentrations of 16alpha and 4 hydroxy estrogens, and lowered risk of cancers of the reproductive tract; and 3) plasma concentrations of estrogen metabolites are associated with genetic polymorphisms in enzymes associated with estrogen metabolism. This study may identify new cancer risk biomarkers that could be used to identify high risk women and to develop dietary and lifestyle strategies for cancer prevention.