SOY ISOFLAVONE DISTRIBUTION IN BIOLOGICAL FLUIDS AS MARKERS OF PROSTATE EXPOSURE

生物体液中大豆异黄酮的分布作为前列腺暴露的标志

• 批准号: 7951696
• 负责人: MINDY SUSAN KURZER
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951696
• 关键词: Biological; Blood; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Consumption; Epidemiology; Exposure to; Funding; Goals; Grant; Individual; Institution; Isoflavones; Liquid substance; Malignant neoplasm of prostate; Measurement; Phytoestrogens; Plasma; Prostate; Research; Research Design; Research Personnel; Resources; Role; Source; Time; Tissues; United States National Institutes of Health; Urine; cancer risk; prostate cancer prevention; research study; soy; soy protein isolate; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research studies indicate that consumption of isoflavone-rich soy lowers prostate cancer risk. The soy components thought to be responsible for this effect are the soy isoflavones (phytoestrogens). As a result, isoflavones are currently being investigated in epidemiological and clinical studies for their possible roles in prostate cancer prevention. It is extremely important in these studies to have an accurate estimate of isoflavone exposure in individuals. Given the inadequacy of dietary methodolgies, biological fluids are considered more reliable indicators of exposure to isoflavones. In designing these studies, researchers have generally assumed that plasma and urinary isoflavone concentrations accurately reflect prostate tissue exposure. However, at this time, no information is available on the validity of this assumption. Thus, the main objective of this proposal is to evaluate the reliability of plasma and urinary isoflavone levels by comparing blood and urine concentrations to more direct measurements of prostate exposure. In order to accomplish this goal, the current study will compare isoflavone levels in plasma and urine with those in expressed prostate secretion (EPS), a widely accepted marker for prostate tissue exposure.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究表明，食用富含大豆黄酮的大豆可以降低患前列腺癌的风险。 大豆成分被认为是负责这种影响是大豆黄酮（植物雌激素）。因此，目前正在流行病学和临床研究中调查前列腺酮在预防前列腺癌中的可能作用。 在这些研究中，准确估计个人的接触量极为重要。鉴于饮食方法的不足，生物液体被认为是更可靠的指标，暴露于异戊烯酮。在设计这些研究时，研究人员通常假设血浆和尿液中的前列腺素浓度准确地反映了前列腺组织的暴露。然而，目前还没有关于这一假设是否有效的信息。 因此，本提案的主要目的是通过比较血液和尿液浓度与更直接的前列腺暴露测量值，评价血浆和尿液中前列腺素水平的可靠性。为了实现这一目标，目前的研究将比较血浆和尿液中的前列腺素水平与表达的前列腺分泌物（EPS）中的前列腺素水平，EPS是一种广泛接受的前列腺组织暴露标志物。