Status Epilepticus Outcomes in the United States

美国癫痫持续状态的结果

• 批准号: 6401663
• 负责人: Edwin Trevathan
• 金额: $ 9.17万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-09 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6401663
• 关键词: bacterial meningitis; brain disorder diagnosis; clinical research; death; disease /disorder proneness /risk; encephalitis; generalized seizures; head /neck injury; health services research tag; hospital patient care; human data; human population study; nervous system disorder therapy; outcomes research; stroke

DESCRIPTION: (taken from abstract) Status epilepticus (SE) is a common, life- threatening medical emergency that is experienced by about 150,000 people in the United States (US) each year, with up to 40,000 SE-associated deaths. In spite of treatments that are often effective, systematic emergency diagnostic and therapeutic protocols for SE are lacking in most hospitals. Unless diagnostic and therapeutic interventions are specifically directed to subpopulations of patients who will benefit most, it is unlikely that significant improvements in the care of patients with SE will be achieved rapidly. Data from the National Inpatient Sample (NIS) of the Healthcare Cost and Utilization Project (HCUP-3) have been recently used to describe the general characteristics of inpatients in the US with SE, and to demonstrate that SE increases the odds of all-cause mortality among inpatients in the US after controlling for co-morbid conditions and other potential confounding variables. Stroke, closed head injury, bacterial meningitis, and viral encephalitis are among the most common significant co-morbidities among hospitalized patients with SE. The long-term goals of our research are to: (a) Characterize the sub- populations of hospitalized patients in the US at highest risk for developing SE, and identify those inpatients who experience a significant increase in the odds of death associated with SE; (b) Propose a systematic intervention strategy for SE diagnosis and treatment for these sub-populations that minimizes medical errors, enhances rapid Diagnosis, and improves clinical outcomes; and (c) Study the effectiveness of the new proposed SE diagnostic and therapeutic delivery system among hospitalized patients. During this one-year grant period, we will extend our initial analyses of SE using the NIS HCUP-3, 1988-1997, to achieve the following Specific Aims: (1) Using the NIS data we will determine the frequency, the trends in frequency, and the geographic variations of SE among hospitalized patients in the US with bacterial meningitis, viral encephalitis, closed head injury, and/or stroke; (2) Using the NIS data, we will determine the impact of SE on the odds of death, controlling for potential confounding variables, among inpatients in the US with bacterial meningitis, viral encephalitis, closed head injury, and/or stroke; (3) Using the NIS data, we will conduct four separate analyses to determine the factors that increase the odds of developing SE among inpatients with bacterial meningitis, viral encephalitis, closed head injuries, and/or stroke.

描述：（摘自摘要）癫痫持续状态（SE）是一种常见的，生活- 威胁医疗紧急情况，约有15万人经历， 美国（US）每年有多达40，000例SE相关死亡。在 尽管治疗通常是有效的，但系统的紧急诊断 大多数医院缺乏SE的治疗方案。除非 诊断和治疗干预特别针对 受益最大的患者亚群， 将显著改善SE患者的护理 迅速数据来自全国住院患者样本（NIS）的医疗保健费用 和利用项目（HCUP-3）最近被用来描述 美国SE住院患者的一般特征，并证明 SE增加了美国住院患者的全因死亡率 在控制共病和其他潜在混杂因素后 变量中风、闭合性脑损伤、细菌性脑膜炎和病毒性脑膜炎 脑炎是其中最常见的重大共病 SE住院患者。 我们的研究的长期目标是：（a）表征亚- 美国住院患者人群中， SE，并确定那些经历了显着增加的住院患者， 与SE相关的死亡几率;（B）提出系统性干预措施 这些亚群SE诊断和治疗策略 最大限度地减少医疗错误，提高快速诊断，并改善临床 （c）研究新提出的社会企业诊断方法的有效性 和治疗输送系统。 在为期一年的资助期内，我们会扩展对社会企业的初步分析， 利用1988-1997年国家信息系统HCUP-3，实现以下具体目标：（1） 使用NIS数据，我们将确定频率，频率趋势， 以及美国住院患者中SE的地理差异， 细菌性脑膜炎、病毒性脑炎、闭合性头部损伤和/或中风; (2)使用NIS数据，我们将确定SE对以下几率的影响： 死亡，控制潜在的混杂变量，在住院患者中， 美国的细菌性脑膜炎，病毒性脑炎，闭合性头部损伤， （3）使用NIS数据，我们将进行四项独立的分析 以确定增加SE发生几率的因素， 细菌性脑膜炎、病毒性脑炎、闭头型 受伤和/或中风。