Aminu Kano Teaching Hospital-Bayero University Kano-Vanderbilt: Developing Future Leaders in Child Neurology and Epilepsy Research (ABV)

翻译后摘要：研究解决癫痫和儿童神经系统疾病的原因，诊断和治疗 在非洲，迫切需要加强对疾病的监测，并提供诊断和治疗服务。的 在非洲，癫痫和儿童神经系统疾病的负担非常高。神经系统综合征， 在撒哈拉以南的非洲已经有了描述，还有更多的可能等待发现。目前，大多数儿童 撒哈拉以南非洲的可治疗神经系统疾病患者（例如，癫痫）既不诊断也不治疗。 大多数儿童神经系统疾病的知识基础是基于北美的研究， 欧洲和环太平洋地区，那里的人口基因组学和环境因果因素与 非洲大规模的流行病学研究、临床试验、诊断技术的开发，以及 需要在非洲开展实施科学研究，以缩小这一知识差距。没有井- 开发了儿童神经学和癫痫研究人员的合作，涵盖了一个大的相对同质的 非洲的儿童。该项目，Aminu Kano教学医院（AKTH）-卡诺Bayero大学 （布克）-范德比尔特：在儿童神经病学和癫痫研究（ABV）的发展未来的领导者，将建立在 范德比尔特、布克和AKTH在儿童领域成功开展NIH资助的合作的坚实基础 在北方尼日利亚--一个人口众多的地区， 超过1亿人，其中一半是儿童。总部设在卡诺，北方尼日利亚的枢纽，ABV将超过 五年为北方尼日利亚的三组未来的研究领导人提供研究培训和指导： (1)五名ABV教职员工被选中在布克开发和教授新课程，以满足未来的需求 儿童神经学和癫痫的研究领导者，在范德比尔特教师的指导下;（2）八个ABV 谁将在布克完成MScPH学位的学者，推出自己的研究项目共同指导 范德比尔特和AKTH/布克教师，并参加范德比尔特研究发展和伦理研究所， 在那里，他们将学习写作，提交和管理自己的赠款;和，（3）八个ABV执行学者， 职业生涯中期的医生调查员，他们将在两年内投入一半的时间来提高他们在某个领域的技能 儿童神经学或癫痫研究，在导师指导下工作，并在布克选修课程。ABV 学者和ABV执行学者将不仅从卡诺，而且从姐妹机构在 尼日利亚北方的其他主要城市--扎里亚、卡杜纳、迈杜古里、卡齐纳和索科托。一岁的孩子 神经病学和癫痫大会将在第三年启动，作为一个区域会议，突出了 ABV研究员、学者和行政学者，计划在2010年前扩大到非洲范围的会议。 5. ABV校友将在尼日利亚的北方形成一个合作网络，以满足关键的研究需求 儿童神经病学和癫痫在ABV项目的前五年，未来的主要研究人员 在准备与所有尼日利亚主要研究人员续签ABV D43资金时，将对ABV的所有人员进行指导。

Abstract: Research addressing the causes, diagnosis, and treatment of epilepsy and childhood neurological disorders, as well as implementation of diagnostic and treatment services, is urgently needed in Africa. The burden of epilepsy and child neurological disorders in Africa is very high. Neurological syndromes unique to sub-Saharan Africa have been described, with many more likely awaiting discovery. Currently most children with treatable neurological disorders in sub-Saharan Africa (e.g., epilepsy) are neither diagnosed nor treated. Most of the knowledge base childhood neurological disorders is based upon research from North America, Europe and the Pacific Rim, where the population genomics and environmental causal factors are different from Africa. Large-scale epidemiology studies, clinical trials, development of diagnostic technologies, and implementation science research in Africa are required to close this knowledge gap. There are no well- developed collaboratives of child neurology and epilepsy researchers that cover a large relatively homogenous population of children in Africa. This project, Aminu Kano Teaching Hospital (AKTH)-Bayero University Kano (BUK)-Vanderbilt: Developing Future Leaders in Child Neurology and Epilepsy Research (ABV), will build upon a solid foundation of successful NIH-funded collaborations between Vanderbilt, BUK and AKTH in child neurology and epilepsy to develop a cadre of physician-scientists in northern Nigeria- a region with a population of over 100 million people, half of whom are children. Based in Kano, the hub of northern Nigeria, ABV will over five years provide research training and mentoring for three groups of future research leaders in northern Nigeria: (1) five ABV Faculty Fellows selected to develop and teach new courses at BUK targeting the needs of future research leaders in child neurology and epilepsy, under the mentorship of Vanderbilt faculty; (2) eight ABV Scholars who will complete the MScPH degree at BUK, launching their own research projects co-mentored by Vanderbilt and AKTH/BUK faculty, and attending the Vanderbilt Institute for Research Development and Ethics, where they will learn to write, submit and administer their own grants; and, (3) eight ABV Executive Scholars, mid-career physician-investigators who will devote half-time for up to two years to enhance their skills in an area of child neurology or epilepsy research, working under a mentor and taking selected courses at BUK . ABV Scholars and ABV Executive Scholars will be recruited from not only Kano, but also from sister institutions in the other major cities within northern Nigeria – Zaria, Kaduna, Maiduguri, Katsina, and Sokoto. A yearly Child Neurology and Epilepsy Congress will be launched in Year 3 as a regional conference highlighting the work of the ABV Fellows, Scholars, and Executive Scholars, with plans to expand to an Africa-wide conference by Year 5. The ABV alumni will form a collaborative network across northern Nigeria to address critical research needs in child neurology and epilepsy. Throughout the first five years of the ABV program future principal investigators of ABV will be mentored as they prepare to renew the ABV D43 funding with all Nigerian principal investigators.