Aminu Kano Teaching Hospital-Bayero University Kano-Vanderbilt: Developing Future Leaders in Child Neurology and Epilepsy Research (ABV)

摘要：关于癫痫和儿童神经病学的病因、诊断和治疗的研究 非洲迫切需要疾病以及诊断和治疗服务的实施。这个 在非洲，癫痫和儿童神经疾病的负担非常高。独有的神经综合征 撒哈拉以南的非洲已经被描述过了，还有更多的可能有待发现。目前大多数儿童 在撒哈拉以南非洲，患有可治疗的神经疾病(如癫痫)的人既没有得到诊断，也没有得到治疗。 大多数儿童神经性障碍的知识库是基于来自北美的研究， 欧洲和环太平洋地区，那里的人口基因组和环境因果因素不同于 非洲。大规模流行病学研究、临床试验、诊断技术的开发，以及 需要在非洲开展实施科学研究，以弥合这一知识差距。没有井- 开发了儿童神经学和癫痫研究人员的合作，涵盖了大量相对同质的 非洲的儿童人口。本项目，阿米努·卡诺教学医院(AKTH)-巴耶罗大学卡诺 (Buk)-Vanderbilt：培养儿童神经学和癫痫研究(ABV)的未来领导者，将在此基础上 NIH资助的Vanderbilt、BUK和AKTH在CHILD中成功合作的坚实基础 神经学和癫痫在尼日利亚北部培养一支内科科学家干部队伍--尼日利亚是一个人口稠密的地区 超过1亿人，其中一半是儿童。总部设在尼日利亚北部中心卡诺的ABV将 五年为尼日利亚北部的三组未来研究领导者提供研究培训和指导： (1)五名ABV学院院士被选中在BUK开发和教授针对未来需求的新课程 在范德比尔特教授的指导下，担任儿童神经病学和癫痫研究带头人；(2)8名ABV 将在BUK完成MScPH学位的学者，推出他们自己的研究项目，由 范德比尔特和AKTH/BUK教职员工，并参加范德比尔特研究发展和伦理研究所， 在那里他们将学习撰写、提交和管理自己的赠款；以及，(3)八名ABV执行学者， 职业生涯中期的内科医生--为提高某一领域的技能，将投入半职时间最多两年的研究人员 在儿童神经学或癫痫研究方面，她在导师的指导下工作，并在BUK参加精选的课程。ABV 学者和ABV执行学者不仅将从卡诺招聘，还将从印度的姐妹机构招聘 尼日利亚北部的其他主要城市--扎里亚、卡杜纳、迈杜古里、卡西纳和索科托。一岁以下的儿童 神经学和癫痫大会将于第三年启动，作为一个地区性会议，重点介绍 ABV研究员、学者和执行学者，计划每年扩大到整个非洲的会议 5.ABV校友将在尼日利亚北部形成一个合作网络，以满足关键的研究需求 在儿童神经病学和癫痫方面。在ABV计划的前五年中，未来的主要研究人员 在准备与尼日利亚所有主要调查人员续签ABV D43资金时，将对ABV的所有主要调查人员进行指导。

Abstract: Research addressing the causes, diagnosis, and treatment of epilepsy and childhood neurological disorders, as well as implementation of diagnostic and treatment services, is urgently needed in Africa. The burden of epilepsy and child neurological disorders in Africa is very high. Neurological syndromes unique to sub-Saharan Africa have been described, with many more likely awaiting discovery. Currently most children with treatable neurological disorders in sub-Saharan Africa (e.g., epilepsy) are neither diagnosed nor treated. Most of the knowledge base childhood neurological disorders is based upon research from North America, Europe and the Pacific Rim, where the population genomics and environmental causal factors are different from Africa. Large-scale epidemiology studies, clinical trials, development of diagnostic technologies, and implementation science research in Africa are required to close this knowledge gap. There are no well- developed collaboratives of child neurology and epilepsy researchers that cover a large relatively homogenous population of children in Africa. This project, Aminu Kano Teaching Hospital (AKTH)-Bayero University Kano (BUK)-Vanderbilt: Developing Future Leaders in Child Neurology and Epilepsy Research (ABV), will build upon a solid foundation of successful NIH-funded collaborations between Vanderbilt, BUK and AKTH in child neurology and epilepsy to develop a cadre of physician-scientists in northern Nigeria- a region with a population of over 100 million people, half of whom are children. Based in Kano, the hub of northern Nigeria, ABV will over five years provide research training and mentoring for three groups of future research leaders in northern Nigeria: (1) five ABV Faculty Fellows selected to develop and teach new courses at BUK targeting the needs of future research leaders in child neurology and epilepsy, under the mentorship of Vanderbilt faculty; (2) eight ABV Scholars who will complete the MScPH degree at BUK, launching their own research projects co-mentored by Vanderbilt and AKTH/BUK faculty, and attending the Vanderbilt Institute for Research Development and Ethics, where they will learn to write, submit and administer their own grants; and, (3) eight ABV Executive Scholars, mid-career physician-investigators who will devote half-time for up to two years to enhance their skills in an area of child neurology or epilepsy research, working under a mentor and taking selected courses at BUK . ABV Scholars and ABV Executive Scholars will be recruited from not only Kano, but also from sister institutions in the other major cities within northern Nigeria – Zaria, Kaduna, Maiduguri, Katsina, and Sokoto. A yearly Child Neurology and Epilepsy Congress will be launched in Year 3 as a regional conference highlighting the work of the ABV Fellows, Scholars, and Executive Scholars, with plans to expand to an Africa-wide conference by Year 5. The ABV alumni will form a collaborative network across northern Nigeria to address critical research needs in child neurology and epilepsy. Throughout the first five years of the ABV program future principal investigators of ABV will be mentored as they prepare to renew the ABV D43 funding with all Nigerian principal investigators.