Helix Packing and Ligand Binding in Dopamine Receptors

多巴胺受体中的螺旋堆积和配体结合

• 批准号: 6341406
• 负责人: Alan Grossfield
• 金额: $ 3.48万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6341406
• 关键词: binding sites; computer simulation; dopamine receptor; ligands; molecular dynamics; postdoctoral investigator; protein structure; rhodopsin

DESCRIPTION (From applicant?s abstract): This is a postdoctoral NRSA application to apply specialized computational approaches to study the structure of dopamine receptors. The three-dimensional structures of G-protein-coupled receptors are not yet known because none of them have been successfully crystallized. However, rhodopsin has been crystallized, although only at relatively low resolution. The candidate will utilize a series of potential energy screening algorithms developed in the sponsor?s laboratory to achieve structural information about dopamine receptors at the atomic level, using known structural information from rhodopsin as a guide. These analyses would begin with the transmembrane segments, then proceed to analyze the potential structure of ligand binding domains of dopamine receptor types.

描述（来自申请人？s abstract）： 这是一个博士后NRSA应用程序应用专门的计算 研究多巴胺受体结构的方法。三维 G蛋白偶联受体的结构尚不清楚，因为 它们已经成功地结晶。然而，视紫红质已经被 结晶，虽然只有在相对较低的分辨率。候选人将 利用一系列势能筛选算法开发的 赞助人？的实验室，以获得有关多巴胺受体的结构信息 在原子水平上，使用视紫红质的已知结构信息作为 为着力这些分析将从跨膜片段开始开始，然后继续进行 分析多巴胺配体结合域的潜在结构 受体类型