HEPATOCYTE GROWTH FACTOR IN FOREBRAIN DEVELOPMENT

前脑发育中的肝细胞生长因子

• 批准号: 6351670
• 负责人: ELIZABETH M POWELL
• 金额: $ 4.2万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6351670
• 关键词: axon; blocking antibody; chemoattractants; collagen; confocal scanning microscopy; developmental neurobiology; embryo /fetus; embryogenesis; ganglions; gene expression; growth factor receptors; hepatocyte growth factor; immunocytochemistry; laboratory mouse; mammalian embryology; neurofilament proteins; neurogenesis; neuronal guidance; prosencephalon; tissue /cell culture

DESCRIPTION Normal development of the cerebral cortex, including the formation of appropriate corticothalamic projects is required for higher sensory and cognitive functions. One would predict that interference in the normal development of these pathways could result in, for example, cognitive defects observed in many congenital birth defects affecting the central nervous system. Furthermore, there is increasing evidence that developmental defects may even underlie disorders that are first manifested later in life. These studies focus on defining how the absence or over-expression of hepatocyte growth factor during development affects the subsequent assembly of normal circuits within the forebrain. The ability to generate animals with abnormal corticothalamic circuits will, in the future, provide models to test how modest defects at the molecular level can lead to long-term abnormalities. Furthermore, an understanding of development mechanisms can be used in the re- establishment of connections after injury.

描述大脑皮层的正常发育，包括形成适当的皮质丘脑项目，是高级感觉和认知功能所必需的。人们可以预测，干扰这些途径的正常发育可能会导致例如在许多影响中枢神经系统的先天性出生缺陷中观察到的认知缺陷。此外，越来越多的证据表明，发育缺陷甚至可能是在生命后期首次表现出来的疾病的基础。这些研究的重点是确定在发育过程中肝细胞生长因子的缺乏或过度表达如何影响前脑内正常回路的后续组装。将来，产生具有异常皮质丘脑回路的动物的能力将提供模型来测试分子水平上的适度缺陷如何导致长期异常。此外，对发育机制的理解可以用于损伤后连接的重建。