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DOSE RESPONSE TO EXERCISE AND CARDIOVASCULAR HEALTH

运动和心血管健康的剂量反应

基本信息

批准号：
6389739
负责人：
MICHAEL G PERRI
金额：
$ 30.91万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-01 至 2003-04-30
项目状态：
已结题

项目摘要

DESCRIPTION: (Adapted from Investigator's Abstract) This project is designed to determine the minimal dose of physical activity necessary to improve cardiovascular (CV) health. More specifically, this 4-year investigation will evaluate and aerobically train 500 healthy men and women, 30-65 years of age. Both the minimal and optimal intensity and frequency of exercise necessary to elicit significant improvements in cardiovascular health will be determined. The plans also include assessment of the effect of specific doses of exercise on the reduction in systolic and diastolic blood pressure and increase in HDL-cholesterol (primary outcomes), in addition to changes in levels of physical activity, aerobic fitness (VO2 max), body composition (% fat and waist-to-hip ratio), triglycerides, and LDL-cholesterol (secondary outcomes). Psychological variables (depression, anxiety, anger, and perceived stress) and health-related quality of life will also be evaluated, and the important issue of adherence to exercise will be examined with respect to the effect of dose of exercise. Subjects will be randomized into one of 5 groups in a 2x2 factorial design plus a usual care control group (n=100 in each of 5 groups). Subjects will train at a moderate (45-55%) or high (65-75% of maximum heart rate reserve) intensity, and at a frequency of 3-4 or 5-7 days/wk (viz., Group 1, 65-75% @ 5-7 d/wk; Group 2, 65-75% @ 3-4 d/wk; Group 3, 45-55% @ 5-7 d/wk; Group 4, 45-55% @ 3-4 d/wk; and, Group 5, usual care control). Controls will receive advice from a physician to increase their physical activity. The subjects in Groups 1-4 will participate in an exercise intervention using walking as the mode of training for a total of 24 months. A lifestyle model of physical activity will be used, in that subjects can accumulate exercise minutes during the day in 10-min increments or more continuously (for a total duration of 30 min/day), and training will be conducted where it is most convenient for the subject (i.e. at home, work or some combination thereof). Tests will occur at baseline (0), 12, and 24 months of the intervention. The application posits that Groups 1-4 will show a significant reduction in systolic and diastolic blood pressure and an increase in HDL-cholesterol compared to the usual care control group. It further suggests that there will be significant main effects for both frequency and intensity, with the higher levels of each producing greater improvement on the major outcome variables compared to the lower levels of each dose. The study is also planned to determine the minimal dose response to exercise necessary to elicit significant improvement in cardiovascular and behavioral health factors. Finally, the project includes examination of the effects of age and level of initial test values on outcome variables to determine if their interactions affect the results of the intervention. The results from the proposed study will provide important data regarding the dose of exercise required to improve CV health, as described both by the NIH Consensus Conference on Physical Activity and CV Health and by the recent Report of the Surgeon General.

描述：(改编自《调查者摘要》)这个项目是旨在确定所需的最低体力活动剂量改善心血管(CV)健康。更具体地说，这四年调查将评估和有氧训练500名健康的男性和女性，年龄在30-65岁之间。最小和最优的强度和频率为显著改善心血管疾病所必需的运动健康状况将会被确定。这些计划还包括对影响的评估特定剂量的运动对降低收缩和舒张压的作用血压和高密度脂蛋白-胆固醇的增加(主要结果) 除了体力活动水平的变化外，有氧健身(VO2 最大)、身体成分(脂肪百分比和腰臀比)、甘油三酯和低密度脂蛋白--胆固醇(次要结果)。心理变量(抑郁、焦虑、愤怒和感受到的压力)和与健康相关的生活质量也将被评估，坚持锻炼的重要问题将根据运动剂量的影响进行检查。科目将在2x2析因设计中随机分成5组常规护理对照组(n=100)，5组各100例。受试者将接受培训处于中等(45%-55%)或高(最大心率储备的65%-75%) 强度，频率为3-4天/周或5-7天/周(即，第1组，65-75%@ 5-7天/周；组2，65-75%；3-4天/周；组3，45-55%，5-7天/周；组4， 45-55%，3-4d/wk；5组，常规护理对照)。控件将收到医生建议增加他们的体力活动。主题在组1-4中，将参与一项使用步行的运动干预该模式共培训24个月。生活方式的典范将使用体力活动，因为受试者可以积累锻炼一天中以10分钟或更长时间为增量的分钟(对于总时长为30分钟/天)，并在所在地点进行培训对对象最方便(例如，在家中、在工作中或在某种组合中其一)。测试将在基线(0)、12和24个月进行干预。该应用程序假定组1-4将显示显著降低收缩压和舒张压，并与常规护理对照组相比，高密度脂蛋白-胆固醇升高。它进一步表明，这两种情况都将产生显著的主要影响频率和强度，每一种的水平越高，产生的主要成果变量与较低水平相比有所改善每一剂。这项研究还计划确定最小剂量反应进行必要的运动以显著改善心血管疾病和行为健康因素。最后，该项目包括审查年龄和初始测试值水平对结果变量的影响确定它们的交互是否会影响干预的结果。这个拟议研究的结果将提供有关 NIH描述的改善简历健康所需的运动量关于体力活动和简历健康的共识会议以及最近卫生局局长的报告。